1. Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression
- Author
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Naoki Oshimori, Sachiko Taniguchi, Sushil Kumar, Justin J. Leitenberger, Avery Van Duzer, and Ajit Elhance
- Subjects
Tumor microenvironment ,Multidisciplinary ,medicine.medical_treatment ,Biology ,Interleukin-33 ,Interleukin 33 ,Paracrine signalling ,Cytokine ,Tumor progression ,Transforming Growth Factor beta ,medicine ,Cancer research ,Carcinoma, Squamous Cell ,Disease Progression ,Neoplastic Stem Cells ,Tumor Microenvironment ,Animals ,Humans ,Signal transduction ,Transcription factor ,Transforming growth factor ,Signal Transduction - Abstract
Deconstructing a perilous loop Cancer cells that give rise to solid tumors reside in a specialized microenvironment containing growth factors that support tumor growth and progression. The mechanisms by which tumor cells within this so-called “niche” attract and sustain these growth factors are poorly understood. Studying a mouse model of squamous cell carcinoma, Taniguchi et al. identified a signaling loop initiated by certain tumor cells within the niche that become more invasive on exposure to transforming growth factor β (TGF-β). They show that the tumor cells release the cytokine interleukin-33, which induces the differentiation of nearby myeloid cells into macrophages. These macrophages in turn release TGF-β, which feeds back to the tumor cells, promoting their malignant progression. Science this issue p. eaay1813
- Published
- 2020