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2. Developmental cell programs are co-opted in inflammatory skin disease

Author

Emily Stephenson, Anna Dubois, C Jones, David McDonald, Tzachi Hagai, Mirjana Efremova, Neil Rajan, Kile Green, Gary Reynolds, Roser Vento-Tormo, James Fletcher, Graham S. Ogg, Sam Behjati, Simone Webb, Elizabeth Poyner, Steven Lisgo, Bayanne Olabi, David Dixon, Edel A. O'Toole, Justin Engelbert, Daniel Maunder, Alexandra-Chloé Villani, Magnus D. Lynch, Victor A. Negri, A. Husain, Ni Huang, Krzysztof Polanski, Dorin-Mirel Popescu, Kerstin B. Meyer, Andrew Filby, Muzlifah Haniffa, Rachel A. Botting, Jim McGrath, Peter Vegh, Laura Jardine, Ben Sayer, Daria Belokhvostova, Fiona M. Watt, Xiao-Nong Wang, Thomas Ness, Dave Horsfall, Nick J. Reynolds, Jaume Bacardit, Sarah A. Teichmann, Jong-Eun Park, Philip H. Jones, Jonathan Coxhead, Christopher D. Carey, and Issac Goh

Subjects
T-Lymphocytes, Cell, Datasets as Topic, Disease, Dermatitis, Atopic, Mice, Atlases as Topic, Single-cell analysis, Cell Movement, Immunity, Psoriasis, Animals, Humans, Medicine, Macrophage, Skin, Phagocytes, Multidisciplinary, Innate immune system, integumentary system, business.industry, Dendritic Cells, Atopic dermatitis, medicine.disease, Immunity, Innate, Methotrexate, medicine.anatomical_structure, Immunology, Dermatologic Agents, Single-Cell Analysis, Transcriptome, business
Abstract

Cellular beauty is skin deep Human skin works as barrier, preventing the entry of pathogens, among other functions. Reynolds et al. used single-cell sequencing to generate an atlas of the human skin from both developing and adult sources, identifying differences and similarities across heterogeneous populations of skin cells. In this atlas, gene expression in the two disease states studied—atopic dermatitis and psoriasis—varied from that in a healthy adult, suggesting that a fetal skin signature is expressed in adult inflamed skin. Furthermore, differences in immune cell composition between healthy fetal and adult skin and that of individuals suffering from disease were observed. Science , this issue p. eaba6500

Published
2021
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