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The clinical characteristics of cocaine addiction, cocaine abstinence symptoms, and the short-term and long-term neurochemical actions of cocaine are discussed. The relative therapeutic value of various medications and treatment programs are discussed. (KR)

Advances in the genetics and cell biology of muscle development are discussed. In-vitro analysis of the renaturation, polymerization, and three-dimensional structure of the purified proteins involved is described. (CW)

The body of data indicating sex differences in the brains of almost every mammalian family examined so far (rodents, birds, monkeys, and human beings) is reviewed. The differences in the hypothalamus, thalamus, corpus callosum, anterior commissure, and the hippocampus are described. (KR)

Described is the discovery that oscillations of electric potential at 40 hertz hold the key to how the brain assembles sense impressions into a single object. Potential implications from this research are discussed. (CW)

Describes the method, present status, and application of positron emission tomography (PET), an analytical imaging technique for "in vivo" measurements of the anatomical distribution and rates of specific biochemical reactions. Measurements and image dynamic biochemistry link basic and clinical neurosciences with clinical findings suggesting hypotheses for laboratory research. (Author/DH)

Discusses the neurobiological basis for functional specialization of the cerebral hemispheres, indicating that the size of the corpus callosum is correlated with the neurophysiological measure of hand preference. In postmortem examinations of 42 subjects there were no sex differences, but mixed-handers had significantly larger total areas of the corpus callosum. (DH)

Focuses on the brain processes and brain systems involved in learning and memory from a neuropsychological perspective of analysis. Reports findings related to the locus of memory storage, types of memory and knowledge, and memory consolidation. Models of animal memory are also examined. An extensive reference list is included. (ML)

Reviews a study which sought to obtain a quantitative metabolic map of the neurons mediating a specific memory. Research results support notions of cooperative processes in which nonrandom behavior of high ensembles of neural elements mediates the integration and processing of information and the retrieval of memory. (ML)

Describes three methods and their advantages and disadvantages for introducing genes into animals. Discusses the predictability and tissue-specificity of the injected genes. Outlines the applications of transgenic technology for studying gene expression, the early stages of mammalian development, mutations, and the molecular nature of chromosomes. (RT)

Describes the diversity of plants. Outlines novel developmental and complex genetic processes that are specific to plants. Identifies approaches that can be used to solve problems in plant biology. Cites the advantages of using higher plants for experimental systems. (RT)

Reports on two longitudinal studies of two-year-old children who were extreme in the display of either behavioral restraint or spontaneity in unfamiliar contexts. Indicates that by age seven most of the restrained group were socially avoidant while the spontaneous children were talkative and interactive. (TW)

Explains the hierarchic structure of the mammalian visual system. Proposes a model in which feedback pathways serve to modify sensory stimuli in ways that enhance and complete sensory input patterns. Investigates the functioning of the system through computer simulations. (ML)

Offers perspectives on the role of extrinsic factors in the aging process, the long-term consequences of extrinsically initiated changes, and implications for gerontological research. Explains the distinction between usual and successful aging in light of physiologic and psychosocial characteristics. (ML)

Discusses the vestibulo-ocular reflex (VOR) which is used to investigate the neural basis for motor learning in monkeys. Suggests organizing principles that may apply in forms of motor learning as a result of similarities among VOR and other motor systems. (Author/RT)

Surveys progress made in understanding the nervous system's ability to direct its attention to one among several objects, move the eye to focus on one of the objects, and generate limb movements in order to grasp and manipulate the object. (Author/RT)

Discusses techniques for studying large-scale brain activity, insights from computational modeling, and cognitive processes that could lead to a better understanding of cognition. Describes interactions between psychology and physiology in perception, structural levels of organization in the nervous system, techniques and research strategies. (RT)

This article reviews the work on patients who have undergone partial or complete brain bisection and addresses the concept of modularity from three different perspectives: (1) structure-function correlations; (2) modular components of cognitive processes; and (3) integration of modular processes. Several brain pictures and diagrams are presented. (YP)

Reviews the vascular anatomy of the pituitary and discusses a series of 14 questions concerning the functional implications of these anatomical observations. Together these questions attempt to identify whether pituitary hormones are transported directly to the brain to modify brain function. (HM)

Selected for discussion are certain advances in basic research and technologic innovation which shape the past, present, and future of medical care. Included are infectious diseases, especially hepatitis, immunology, clinical disorders of the immune system and the histocompatability system. (Author/SA)

Briefly reviews the early history of industrial microbiology and discusses industrial fermentation practices and the role of recombinant DNA in the fermentation industry. (SK)

Studies demonstrate increasing glucose metabolic rates in human primary (PVC) and association (AVC) visual cortex as complexity of visual scenes increase. AVC increased more rapidly with scene complexity than PVC and increased local metabolic activities above control subject with eyes closed; indicates wide range and metabolic reserve of visual cortex. (DS)

Electroencephalograms were analyzed during performance of verbal and spatial tasks. Complex scalp distributions of theta-, beta-, and, to a lesser extent, alpha-band spectral intensities discriminated between the two members of a pair of tasks, such as writing sentences and Koh's block design. (Author/BB)

It has recently been shown that perceived motion, in the absence of any appropriate retinal motion, is a sufficient stimulus to generate smooth pursuit eye motions. However, three experiments show that perceived motion is not necessary for pursuit, but that retinal motion always governs pursuit. (BB)

A new method generates specific predictions concerning the expected frequencies of aphasia after unilateral injury to the brain in the left- and right-handed. These predictions are then compared with the observed data for all known studies between 1935 and 1973 to derive the best-fitting model of hemispheric speech lateralization in the left- and right-handed. (Author/BB)

Assesses the sensory and cognitive functions in a right-handed male before and after partial and complete callosal commissurotomy. (Author/SK)

Stabilization of the retinal image of the boundary between a pair of red/green or yellow/blue stripes, but not their outer edges, results in the entire region being perceived simultaneously as both red/green or yellow/blue. This suggests that the percepts of reddish-green/yellowish-blue apparently are possible in corticocortical color vision processes. (JN)

The question as to whether males and females have different kinds of intellectual abilities is addressed. The evidence that there are some differences in cognition and perception between men and women is reviewed. (KR)

Discussed is the discovery which may help to explain epidermal growth factor effects on the cell skeleton. The role of a protein called profilin in the regulation of the microfilament system is described. (CW)