1. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
- Author
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Kandeh Kargbo, Stephen F. Schaffner, S. Humarr Khan, John S. Scheiffelin, Kristian G. Andersen, Fatima K. Kamara, Sarah M. Winnicki, Mambu Momoh, Michael Gbakie, Sidiki Saffa, Chad Nusbaum, Mohamed Yillah, Lina M. Moses, Nathan L. Yozwiak, Augustine Goba, James Koninga, Mbalu Fonnie, Alice Kovoma, Franklyn Kanneh, Simbirie Jalloh, Christian B. Matranga, Lansana Kanneh, Willie Robert, James Qu, Christian T. Happi, Bruce W. Birren, Gytis Dudas, Mohamed Fullah, Sarah Young, Pardis C. Sabeti, Sahr M. Gevao, Ibrahim Mustapha, Moinya Ruth Coomber, Alex Moigboi, Eric S. Lander, Robert F. Garry, Daniel J. Park, Stephen K. Gire, Rachel Sealfon, James L.B. Massally, Donald S. Grant, Adrianne Gladden, Cheryl I. Murphy, Momoh Foday, Abdul A. Jalloh, Josephine Sellu, Andrés Colubri, Sinéad B. Chapman, Xiao Yang, Christine M. Malboeuf, Andreas Gnirke, Pan Pan Jiang, Mahan Nekoui, Edwin Konuwa, Veronica Tucker, Shirlee Wohl, Andrew Rambaut, and James Bochicchio
- Subjects
Zaire ebolavirus ,viruses ,Genome, Viral ,Disease ,Biology ,medicine.disease_cause ,Article ,Sierra Leone ,Disease Outbreaks ,Sierra leone ,Genetic variation ,medicine ,Humans ,Ebolavirus ,Multidisciplinary ,Ebola virus ,Base Sequence ,Transmission (medicine) ,Genetic Variation ,Outbreak ,Genomics ,Sequence Analysis, DNA ,Hemorrhagic Fever, Ebola ,Virology ,Mutation ,Epidemiological Monitoring - Abstract
Evolution of Ebola virus over time The high rate of mortality in the current Ebola epidemic has made it difficult for researchers to collect samples of the virus and study its evolution. Gire et al. describe Ebola epidemiology on the basis of 99 whole-genome sequences, including samples from 78 affected individuals. The authors analyzed changes in the viral sequence and conclude that the current outbreak probably resulted from the spread of the virus from central Africa in the past decade. The outbreak started from a single transmission event from an unknown animal reservoir into the human population. Two viral lineages from Guinea then spread from person to person into Sierra Leone. Science , this issue p. 1369
- Published
- 2014