1. Comment on 'Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death'
- Author
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Abdel Aouacheria, Ted Powers, J. Marie Hardwick, Zdena Palková, Kyle W. Cunningham, Fedor F. Severin, Libuše Váchová, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Department of Pharmacology and Molecular Sciences, Johns Hopkins University (JHU), BioCeV-Institute of Microbiology, Department of Cellular Machines, BioTechnological Center, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Institute of Microbiology of the ASCR, v. v. i. [Prague, Czech Republic], R01 NS083373/NS/NINDS NIH HHS/United States, R21 NS096677/NS/NINDS NIH HHS/United States, R01 GM077875/GM/NIGMS NIH HHS/United States, R21 AI115016/AI/NIAID NIH HHS/United States, Fondation ARC, Ligue Contre le Cancer Comité du Gard, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)
- Subjects
MESH: Cell Death ,0301 basic medicine ,Programmed cell death ,animal structures ,MESH: Apoptosis/immunology ,medicine.medical_treatment ,Apoptosis ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,Aspergillosis ,Article ,Microbiology ,Aspergillus fumigatus ,03 medical and health sciences ,MESH: Lung/immunology ,Immunity ,[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] ,Survivin ,otorhinolaryngologic diseases ,Homologous chromosome ,medicine ,Humans ,MESH: Aspergillus fumigatus/immunology ,[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,Lung ,MESH: Humans ,Multidisciplinary ,Protease ,Cell Death ,biology ,[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,MESH: Aspergillosis/immunology ,biology.organism_classification ,medicine.disease ,3. Good health ,030104 developmental biology ,[SDV.IMM]Life Sciences [q-bio]/Immunology - Abstract
Shlezinger et al . (Reports, 8 September 2017, p. 1037) report that the common fungus Aspergillus fumigatus , a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin.
- Published
- 2018
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