Search

Your search keyword '"Kafatos A."' showing total 46 results
Start Over Author "Kafatos A." Journal science
46 results on '"Kafatos A."'

1. A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses

Author

Hall, Neil, Karras, Marianna, Raine, J. Dale, Carlton, Jane M., Berriman, Matthew, Florens, Laurence, Janssen, Christoph S., Pain, Arnab, Christophides, Georges K., James, Keith, Rutherford, Kim, Harris, Barbara, Harris, David, Churcher, Carol, Quail, Michael A., Ormond, Doug, Doggett, Jon, Trueman, Holly E., Mendoza, Jacqui, Bidwell, Shelby L., Rajandream, Marie-Adele, Carucci, Daniel J., Yates, John R., Kafatos, Fotis C., Janse, Chris J., Barrell, Bart, Waters, Andrew P., and Sinden, Robert E.

Published
2005

2. Mosquito: Anopheles gambiae

Author

Jasny, Barbara R., Smith, Orla M., Coluzzi, Mario, Collins, Frank H., Hoffman, Stephen L., Holt, Robert A., Kafatos, Fotis C., Aultman, Kathryn S., James, Anthony A., Knudson, Dennis L., Townson, Harold, Smith, C. Faber, Stonebraker, Alan, Sutliff, Katharine, Tompkins, David M., and Jach, Harry

Published
2002

3. Immunity-Related Genes and Gene Families in Anopheles gambiae

Author

Christophides, George K., Zdobnov, Evgeny, Barillas-Mury, Carolina, Birney, Ewan, Blandin, Stephanie, Blass, Claudia, Brey, Paul T., Collins, Frank H., Danielli, Alberto, Dimopoulos, George, Hetru, Charles, Hoa, Ngo T., Hoffmann, Jules A., Kanzok, Stefan M., Letunic, Ivica, Levashina, Elena A., Loukeris, Thanasis G., Lycett, Gareth, Meister, Stephan, Michel, Kristin, Moita, Luis F., Müller, Hans-Michael, Osta, Mike A., Paskewitz, Susan M., Reichhart, Jean-Marc, Rzhetsky, Andrey, Troxler, Laurent, Vernick, Kenneth D., Vlachou, Dina, Volz, Jennifer, von Mering, Christian, Xu, Jiannong, Zheng, Liangbiao, Bork, Peer, and Kafatos, Fotis C.

Published
2002

4. The Genome Sequence of the Malaria Mosquito Anopheles gamblae

Author

Holt, Robert A., Subramanian, G. Mani, Halpern, Aaron, Sutton, Granger G., Charlab, Rosane, Nusskern, Deborah R., Wincker, Patrick, Clark, Andrew G., Wides, Ron, Salzberg, Steven L., Loftus, Brendan, Yandell, Mark, Majoros, William H., Rusch, Douglas B., Lai, Zhongwu, Kraft, Cheryl L., Abril, Josep F., Anthouard, Veronique, Arensburger, Peter, Atkinson, Peter W., Baden, Holly, de Berardinis, Veronique, Baldwin, Danita, Benes, Vladimir, Biedler, Jim, Blass, Claudia, Bolanos, Randall, Boscus, Didier, Barnstead, Mary, Cai, Shuang, Chatuverdi, Kabir, Christophides, George K., Chrystal, Mathew A., Clamp, Michele, Cravchik, Anibal, Curwen, Val, Dana, Ali, Delcher, Art, Dew, Ian, Evans, Cheryl A., Flanigan, Michael, Grundschober-Freimoser, Anne, Friedli, Lisa, Gu, Zhiping, Guan, Ping, Guigo, Roderic, Hillenmeyer, Maureen E., Hladun, Susanne L., Hogan, James R., Hong, Young S., Hoover, Jeffrey, Jaillon, Olivier, Ke, Zhaoxi, Kodira, Chinnappa, Kokoza, Elena, Koutsos, Anastasios, Letunic, Ivica, Levitsky, Alex, Liang, Yong, Lin, Jhy-Jhu, Lobo, Neil F., Lopez, John R., Malek, Joel A., McIntosh, Tina C., Meister, Stephan, Miller, Jason, Mobarry, Clark, Mongin, Emmanuel, Murphy, Sean D., O'Brochta, David A., Pfannkoch, Cynthia, Qi, Rong, Regier, Megan A., Remington, Karin, Shao, Hongguang, Sharakhova, Maria V., Sitter, Cynthia D., Shetty, Jyoti, Smith, Thomas J., Strong, Renee, Sun, Jingtao, Thomasova, Dana, Ton, Lucas Q., Topalis, Pantelis, Tu, Zhijian, Unger, Maria F., Walenz, Brian, Wang, Aihui, Wang, Jian, Wang, Mei, Wang, Xuelan, Woodford, Kerry J., Wortman, Jennifer R., Wu, Martin, Yao, Alison, Zdobnov, Evgeny M., Zhang, Hongyu, Zhao, Qi, Zhao, Shaying, Zhu, Shiaoping C., Zhimulev, Igor, Coluzzi, Mario, della Torre, Alessandra, Roth, Charles W., Louis, Christos, Kalush, Francis, Mural, Richard J., Myers, Eugene W., Adams, Mark D., Smith, Hamilton O., Broder, Samuel, Gardner, Malcolm J., Fraser, Claire M., Birney, Ewan, Bork, Peer, Brey, Paul T., Venter, J. Craig, Weissenbach, Jean, Kafatos, Fotis C., Collins, Frank H., and Hoffman, Stephen L.

Published
2002

5. Comparative Genome and Proteome Analysis of Anopheles gambiae and Drosophila melanogaster

Author

Zdobnov, Evgeny M., von Mering, Christian, Letunic, Ivica, Torrents, David, Suyama, Mikita, Copley, Richard R., Christophides, George K., Thomasova, Dana, Holt, Robert A., Subramanian, G. Mani, Mueller, Hans-Michael, Dimopoulos, George, Law, John H., Wells, Michael A., Birney, Ewan, Charlab, Rosane, Halpern, Aaron L., Kokoza, Elena, Kraft, Cheryl L., Lai, Zhongwu, Lewis, Suzanna, Louis, Christos, Barillas-Mury, Carolina, Nusskern, Deborah, Rubin, Gerald M., Salzberg, Steven L., Sutton, Granger G., Topalis, Pantelis, Wides, Ron, Wincker, Patrick, Yandell, Mark, Collins, Frank H., Ribeiro, Jose, Gelbart, William M., Kafatos, Fotis C., and Bork, Peer

Published
2002

10. Malaria Control with Genetically Manipulated Insect Vectors

Author

Alphey, Luke, Ben Beard, C., Billingsley, Peter, Coetzee, Maureen, Crisanti, Andrea, Curtis, Chris, Eggleston, Paul, Godfray, Charles, Hemingway, Janet, Jacobs-Lorena, Marcelo, James, Anthony A., Kafatos, Fotis C., Mukwaya, Louis G., Paton, Michael, Powell, Jeffrey R., Schneider, William, Scott, Thomas W., Sina, Barbara, Sinden, Robert, Sinkins, Steven, Spielman, Andrew, Touré, Yeya, and Collins, Frank H.

Published
2002

11. From Sequence to Chromosome: The Tip of the X Chromosome of D. melanogaster

Author

Benos, Panayiotis V., Gatt, Melanie K., Ashburner, Michael, Murphy, Lee, Harris, David, Barrell, Bart, Ferraz, Concepcion, Vidal, Sophie, Brun, Christine, Demailles, Jacques, Cadieu, Edouard, Dreano, Stephane, Gloux, Stéphanie, Lelaure, Valerie, Mottier, Stephanie, Galibert, Francis, Borkova, Dana, Minana, Belen, Kafatos, Fotis C., Louis, Christos, Sidén-Kiamos, Inga, Bolshakov, Slava, Papagiannakis, George, Spanos, Lefteris, Cox, Sarah, Madueño, Encarnación, de Pablos, Beatriz, Modolell, Juan, Peter, Annette, Schöttler, Petra, Werner, Meike, Mourkioti, Foteini, Beinert, Nicole, Dowe, Gordon, Schäfer, Ulrich, Jäckle, Herbert, Bucheton, Alain, Callister, Deborah M., Campbell, Lorna A., Darlamitsou, Areti, Henderson, Nadine S., McMillan, Paul J., Salles, Cathy, Tait, Evelyn A., Valenti, Phillipe, and Glover, David M.

Published
2000

13. Widespread Divergence Between Incipient Anopheles gambiae Species Revealed by Whole Genome Sequences

Author

Lawniczak, M. K. N., Emrich, S. J., Holloway, A. K., Regier, A. P., Olson, M., White, B., Redmond, S., Fulton, L., Appelbaum, E., Godfrey, J., Farmer, C., Chinwalla, A., Yang, S.-P., Minx, P., Nelson, J., Kyung, K., Walenz, B. P., Garcia-Hernandez, E., Aguiar, M., Viswanathan, L. D., Rogers, Y.-H., Strausberg, R. L., Saski, C. A., Lawson, D., Collins, F. H., Kafatos, F. C., Christophides, G. K., Clifton, S. W., Kirkness, E. F., and Besansky, N. J.

Published
2010

15. Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes

Author

Waterhouse, Robert M., Kriventseva, Evgenia V., Meister, Stephan, Xi, Zhiyong, Alvarez, Kanwal S., Bartholomay, Lyric C., Barillas-Mury, Carolina, Bian, Guowu, Blandin, Stephanie, Christensen, Bruce M., Dong, Yuemei, Jiang, Haobo, Kanost, Michael R., Koutsos, Anastasios C., Levashina, Elena A., Li, Jianyong, Ligoxygakis, Petros, MacCallum, Robert M., Mayhew, George F., Mendes, Antonio, Michel, Kristin, Osta, Mike A., Paskewitz, Susan, Shin, Sang Woon, Vlachou, Dina, Wang, Lihui, Wei, Weiqi, Zheng, Liangbiao, Zou, Zhen, Severson, David W., Raikhel, Alexander S., Kafatos, Fotis C., Dimopoulos, George, Zdobnov, Evgeny M., and Christophides, George K.

Published
2007
Full Text
View/download PDF

16. Genome Maps 1991

Author

Rosin, David, Chipperfield, Michael, Maidak, Bonnie, Pearson, Peter, Ashburner, Michael, Glover, David M., Duncan, Ian, Hartl, Daniel, Merriam, John, Lee, Geunbae, Johnsen, Joy, Kafatos, Fotis C., Sidén-Kiamos, Inga, Louis, Christos, and Savakis, Charalambos

Published
1991

26. Genome maps 1991

Author

Chipperfield, Michael, Maidak, Bonnie, Pearson, Peter, Ashburner, Michael, Glover, David M., Saunders, Robert D.C., Duncan, Ian, Hartl, Daniel, Merriam, John, Lee, Geunbae, Johnsen, Joy, Kafatos, Fotis C., Siden-Kiamos, Inga, Louis, Christos, Savakis, Charalambos, and Nowoslawski, Susan

Subjects
Genetic aspects, Portrayals, Drosophila -- Genetic aspects, Chromosome mapping -- Portrayals -- Genetic aspects, Genomes -- Portrayals -- Genetic aspects
Abstract

The wall chart this year is divided in two parts. At the top is presented an update of progress in the human genome. There have also been major advances in [...]

Published
1991

29. Immunity-Related Genes and Gene Families in Anopheles gambiae

Author

Gareth J Lycett, Andrey Rzhetsky, Kenneth D. Vernick, Christian von Mering, Jiannong Xu, Frank H. Collins, Claudia Blass, Jules A. Hoffmann, Peer Bork, Stefan M. Kanzok, Jean-Marc Reichhart, Elena A. Levashina, Thanasis G. Loukeris, Stephan Meister, Charles Hetru, Ivica Letunic, Ngo Thi Hoa, Fotis C. Kafatos, Stéphanie Blandin, Liangbiao Zheng, Carolina Barillas-Mury, Mike A. Osta, Hans-Michael Müller, Jennifer Volz, Evgeny M. Zdobnov, Luis F. Moita, George Dimopoulos, Kristin Michel, Paul T. Brey, Laurent Troxler, Dina Vlachou, George K. Christophides, Susan M. Paskewitz, Ewan Birney, Alberto Danielli, Christophides G.K., Zdobnov E., Barillas-Mury C., Birney E., Blandin S., Blass C., Brey P.T., Collins F.H., Danielli A., Dimopoulos G., Hetru C., Hoa N.T., Hoffmann J.A., Kanzok S.M., Letunic I., Levashina E.A., Loukeris T.G., Lycett G., Meister S., Michel K., Moita L.F., Muller H.-M., Osta M.A., Paskewitz S.M., Reichhart J.-M., Rzhetsky A., Troxler L., Vernick K.D., Vlachou D., Volz J., Von Mering C., Xu J., Zheng L., Bork P., and Kafatos F.C.

Subjects
Plasmodium, Serpins/metabolism, Drosophila melanogaster/genetics/immunology/metabolism, Anopheles gambiae, Apoptosis, Genes, Insect, Peptides/metabolism, Insect Protein, Drosophila Proteins, Enzyme Precursors/metabolism, Catechol Oxidase/metabolism, Phylogeny, Serpin, ddc:616, Genetics, Enzyme Precursors, Genome, Multidisciplinary, Drosophila Proteins/chemistry/genetics/metabolism, Effector, Serine Endopeptidases, Insect Proteins/chemistry/genetics/metabolism, Serine Endopeptidase, Drosophila melanogaster, Multigene Family, Peptide, Plasmodium/immunology/physiology, Insect Proteins, Anophele, Catechol Oxidase, Signal Transduction, Bacteria/immunology, Biology, Enzyme Precursor, Serine Endopeptidases/metabolism, Immune system, Anopheles, Animals, Anopheles/ genetics/ immunology/metabolism/microbiology/parasitology, Gene family, Selection, Genetic, Gene, Serpins, Innate immune system, Bacteria, Animal, Alternative splicing, Apoptosi, Computational Biology, biology.organism_classification, Immunity, Innate, Protein Structure, Tertiary, Alternative Splicing, Gene Expression Regulation, Drosophila Protein, Peptides
Abstract

We have identified 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity and have detected marked diversification relative to Drosophila melanogaster . Immune-related gene families involved in recognition, signal modulation, and effector systems show a marked deficit of orthologs and excessive gene expansions, possibly reflecting selection pressures from different pathogens encountered in these insects' very different life-styles. In contrast, the multifunctional Toll signal transduction pathway is substantially conserved, presumably because of counterselection for developmental stability. Representative expression profiles confirm that sequence diversification is accompanied by specific responses to different immune challenges. Alternative RNA splicing may also contribute to expansion of the immune repertoire.

Published
2002
Full Text
View/download PDF

30. The Genome Sequence of the Malaria Mosquito Anopheles gambiae

Author

Mei Wang, Frank H. Collins, Yong Liang, José M. C. Ribeiro, Zhijian Tu, Jason R. Miller, Mark Yandell, Pantelis Topalis, Hongguang Shao, Qi Zhao, Hamilton O. Smith, Ali N Dana, Zhaoxi Ke, J. Craig Venter, Deborah R. Nusskern, Christos Louis, Ivica Letunic, Brian P. Walenz, Granger G. Sutton, Patrick Wincker, Anastasios C. Koutsos, Paul T. Brey, Ewan Birney, Jean Weissenbach, Fotis C. Kafatos, Cheryl A. Evans, Kerry J. Woodford, Dana Thomasova, Eugene W. Myers, Stephen L. Hoffman, Kokoza Eb, Josep F. Abril, Randall Bolanos, Megan A. Regier, Holly Baden, George K. Christophides, Véronique de Berardinis, Jingtao Sun, James R. Hogan, Kabir Chatuverdi, Ron Wides, Emmanuel Mongin, Igor F. Zhimulev, Steven L. Salzberg, Danita Baldwin, Richard J. Mural, Shiaoping C. Zhu, Anibal Cravchik, Jhy-Jhu Lin, G. Mani Subramanian, Young S. Hong, Shuang Cai, Francis Kalush, Rosane Charlab, Martin Wu, Claudia Blass, Mark Raymond Adams, Robert A. Holt, Clark M. Mobarry, Douglas B. Rusch, Michael Flanigan, Jim Biedler, Susanne L. Hladun, Ping Guan, Cynthia Sitter, Joel A. Malek, Mario Coluzzi, Cynthia Pfannkoch, Arthur L. Delcher, Alessandra della Torre, Maria F. Unger, Evgeny M. Zdobnov, Stephan Meister, Karin A. Remington, Peter W. Atkinson, Malcolm J. Gardner, Vladimir Benes, Ian M. Dew, Maria V. Sharakhova, X. Wang, Hongyu Zhang, Jian Wang, Jeffrey Hoover, Cheryl L. Kraft, Charles Roth, Andrew G. Clark, Shaying Zhao, Jyoti Shetty, Tina C. McIntosh, Aihui Wang, Zhiping Gu, Aaron L. Halpern, Anne Grundschober-Freimoser, David A. O'Brochta, Peter Arensburger, Brendan J. Loftus, Lucas Q. Ton, Véronique Anthouard, Mary Barnstead, John Lopez, Peer Bork, Didier Boscus, Michele Clamp, Jennifer R. Wortman, Claire M. Fraser, Lisa Friedli, William H. Majoros, Thomas J. Smith, Olivier Jaillon, Val Curwen, Samuel Broder, Sean D. Murphy, Roderic Guigó, Neil F. Lobo, Mathew A. Chrystal, Alison Yao, Alex Levitsky, Renee Strong, Maureen E. Hillenmeyer, Zhongwu Lai, Chinnappa D. Kodira, Rong Qi, and Zdobnov, Evgeny

Subjects
Chromosomes, Artificial, Bacterial, Drosophila melanogaster/genetics, Mosquito Control, Proteome, Enzymes/chemistry/genetics/metabolism, Anopheles gambiae, Genes, Insect, Genome, Plasmodium falciparum/growth & development, Malaria, Falciparum, Expressed Sequence Tags, Genetics, Expressed sequence tag, Multidisciplinary, Physical Chromosome Mapping, Biological Evolution, Enzymes, Blood, Drosophila melanogaster, Insect Proteins, Digestion, Sequence analysis, Molecular Sequence Data, Plasmodium falciparum, Biology, Polymorphism, Single Nucleotide, Species Specificity, Anopheles, Genetic variation, Transcription Factors/chemistry/genetics/physiology, Animals, Humans, Insect Proteins/chemistry/genetics/physiology, Malaria, Falciparum/transmission, Gene, Anopheles/classification/genetics/parasitology/physiology, Whole genome sequencing, Haplotype, Computational Biology, Genetic Variation, Feeding Behavior, Sequence Analysis, DNA, biology.organism_classification, Insect Vectors, Gene Expression Regulation, Haplotypes, Chromosome Inversion, DNA Transposable Elements, Insect Vectors/genetics/parasitology/physiology, Transcription Factors
Abstract

Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes more than 1 million deaths each year. Tenfold shotgun sequence coverage was obtained from the PEST strain of A. gambiae and assembled into scaffolds that span 278 million base pairs. A total of 91% of the genome was organized in 303 scaffolds; the largest scaffold was 23.1 million base pairs. There was substantial genetic variation within this strain, and the apparent existence of two haplotypes of approximately equal frequency (“dual haplotypes”) in a substantial fraction of the genome likely reflects the outbred nature of the PEST strain. The sequence produced a conservative inference of more than 400,000 single-nucleotide polymorphisms that showed a markedly bimodal density distribution. Analysis of the genome sequence revealed strong evidence for about 14,000 protein-encoding transcripts. Prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted. An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect.

Published
2002
Full Text
View/download PDF

33. A Detailed Genetic Map for the X Chromosome of the Malaria Vector, Anopheles gambiae

Author

Frank H. Collins, Liangbiao Zheng, Fotis C. Kafatos, and Vasantha Kumar

Subjects
Genetic Markers, Male, X Chromosome, Anopheles gambiae, Molecular Sequence Data, Genes, Insect, Genes, Recessive, DNA, Satellite, Centimorgan, Gene mapping, Anopheles, parasitic diseases, Animals, Alleles, Crosses, Genetic, X chromosome, Recombination, Genetic, Genetics, Multidisciplinary, Base Sequence, biology, Chromosome Mapping, biology.organism_classification, Chromosome Banding, Insect Vectors, Malaria, Genetic marker, Vector (epidemiology), Mutation, Mutation (genetic algorithm), Female
Abstract

Anopheles gambiae, the primary vector of human malaria in Africa, is responsible for approximately a million deaths per year, mostly of children. Despite its significance in disease transmission, this mosquito has not been studied extensively by genetic or molecular techniques. To facilitate studies on this vector, a genetic map has been developed that covers the X chromosome at an average resolution of 2 centimorgans. This map has been integrated with the chromosome banding pattern and used to localize a recessive, sex-linked mutation (white eye) to within 1 centimorgan of flanking markers.

Published
1993
Full Text
View/download PDF

34. Multiple zinc finger forms resulting from developmentally regulated alternative splicing of a transcription factor gene

Author

Susan A. Kirsh, Joseph A. Gogos, Fotis C. Kafatos, and Tien Hsu

Subjects
Gene isoform, RNA Splicing, Molecular Sequence Data, Biology, Polymerase Chain Reaction, Gene product, Animals, Drosophila Proteins, Amino Acid Sequence, RNA, Messenger, Transcription factor, Genetics, Zinc finger, Messenger RNA, Multidisciplinary, Base Sequence, Alternative splicing, Zinc Fingers, Promoter, Chorion, DNA-Binding Proteins, Drosophila melanogaster, Gene Expression Regulation, Genes, Oligodeoxyribonucleotides, Transcription Factor Gene, Sequence Alignment, Transcription Factors
Abstract

Transcripts encoding the Drosophila putative transcription factor CF2 are subject to developmentally regulated alternative splicing, and they encode protein isoforms that differ in the number of zinc fingers. One testis-specific RNA encodes an isoform that includes three zinc fingers and a frame-shifted segment. Two other transcripts encode isoforms with six and seven zinc fingers which bind to distinct promoters and DNA target sequences. Thus, because of alternative splicing, a single gene appears to encode distinct DNA-binding proteins, each capable of regulating different gene sets in different tissues and developmental periods.

Published
1992
Full Text
View/download PDF

35. Toward Cloning And Mapping the Genome of Drosophila

Author

FC Kafatos, Daniel L. Hartl, John R. Merriam, and Michael Ashburner

Subjects
Genomics, Computational biology, Biology, medicine.disease_cause, Genome, Chromosomes, DNA sequencing, medicine, Animals, Cloning, Molecular, Gene, Gene Rearrangement, Genetics, Mutation, Multidisciplinary, Base Sequence, Chromosome Mapping, Gene rearrangement, Genome project, biology.organism_classification, Biological Evolution, Drosophila melanogaster, Genes
Abstract

An ultimate goal of Drosophila genetics is to identify and define the functions of all the genes in the organism. Traditional approaches based on the isolation of mutant genes have been extraordinary fruitful. Recent advances in the manipulation and analysis of large DNA fragments have made it possible to develop detailed molecular maps of the Drosophila genome as the initial steps in determining the complete DNA sequence.

Published
1991
Full Text
View/download PDF

36. Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes

Author

Neafsey, Daniel E., primary, Waterhouse, Robert M., additional, Abai, Mohammad R., additional, Aganezov, Sergey S., additional, Alekseyev, Max A., additional, Allen, James E., additional, Amon, James, additional, Arcà, Bruno, additional, Arensburger, Peter, additional, Artemov, Gleb, additional, Assour, Lauren A., additional, Basseri, Hamidreza, additional, Berlin, Aaron, additional, Birren, Bruce W., additional, Blandin, Stephanie A., additional, Brockman, Andrew I., additional, Burkot, Thomas R., additional, Burt, Austin, additional, Chan, Clara S., additional, Chauve, Cedric, additional, Chiu, Joanna C., additional, Christensen, Mikkel, additional, Costantini, Carlo, additional, Davidson, Victoria L. M., additional, Deligianni, Elena, additional, Dottorini, Tania, additional, Dritsou, Vicky, additional, Gabriel, Stacey B., additional, Guelbeogo, Wamdaogo M., additional, Hall, Andrew B., additional, Han, Mira V., additional, Hlaing, Thaung, additional, Hughes, Daniel S. T., additional, Jenkins, Adam M., additional, Jiang, Xiaofang, additional, Jungreis, Irwin, additional, Kakani, Evdoxia G., additional, Kamali, Maryam, additional, Kemppainen, Petri, additional, Kennedy, Ryan C., additional, Kirmitzoglou, Ioannis K., additional, Koekemoer, Lizette L., additional, Laban, Njoroge, additional, Langridge, Nicholas, additional, Lawniczak, Mara K. N., additional, Lirakis, Manolis, additional, Lobo, Neil F., additional, Lowy, Ernesto, additional, MacCallum, Robert M., additional, Mao, Chunhong, additional, Maslen, Gareth, additional, Mbogo, Charles, additional, McCarthy, Jenny, additional, Michel, Kristin, additional, Mitchell, Sara N., additional, Moore, Wendy, additional, Murphy, Katherine A., additional, Naumenko, Anastasia N., additional, Nolan, Tony, additional, Novoa, Eva M., additional, O’Loughlin, Samantha, additional, Oringanje, Chioma, additional, Oshaghi, Mohammad A., additional, Pakpour, Nazzy, additional, Papathanos, Philippos A., additional, Peery, Ashley N., additional, Povelones, Michael, additional, Prakash, Anil, additional, Price, David P., additional, Rajaraman, Ashok, additional, Reimer, Lisa J., additional, Rinker, David C., additional, Rokas, Antonis, additional, Russell, Tanya L., additional, Sagnon, N’Fale, additional, Sharakhova, Maria V., additional, Shea, Terrance, additional, Simão, Felipe A., additional, Simard, Frederic, additional, Slotman, Michel A., additional, Somboon, Pradya, additional, Stegniy, Vladimir, additional, Struchiner, Claudio J., additional, Thomas, Gregg W. C., additional, Tojo, Marta, additional, Topalis, Pantelis, additional, Tubio, José M. C., additional, Unger, Maria F., additional, Vontas, John, additional, Walton, Catherine, additional, Wilding, Craig S., additional, Willis, Judith H., additional, Wu, Yi-Chieh, additional, Yan, Guiyun, additional, Zdobnov, Evgeny M., additional, Zhou, Xiaofan, additional, Catteruccia, Flaminia, additional, Christophides, George K., additional, Collins, Frank H., additional, Cornman, Robert S., additional, Crisanti, Andrea, additional, Donnelly, Martin J., additional, Emrich, Scott J., additional, Fontaine, Michael C., additional, Gelbart, William, additional, Hahn, Matthew W., additional, Hansen, Immo A., additional, Howell, Paul I., additional, Kafatos, Fotis C., additional, Kellis, Manolis, additional, Lawson, Daniel, additional, Louis, Christos, additional, Luckhart, Shirley, additional, Muskavitch, Marc A. T., additional, Ribeiro, José M., additional, Riehle, Michael A., additional, Sharakhov, Igor V., additional, Tu, Zhijian, additional, Zwiebel, Laurence J., additional, and Besansky, Nora J., additional

Published
2015
Full Text
View/download PDF

37. Unification in the century of biology

Author

Kafatos, Fotis C. and Eisner, Thomas

Subjects
Models, Study and teaching, Forecasts and trends, Market trend/market analysis, Biology -- Study and teaching -- Models -- Forecasts and trends, Interdisciplinary research -- Forecasts and trends -- Study and teaching -- Models
Abstract

Scientific progress is based ultimately on unification rather than fragmentation of knowledge. At the threshold of what is widely regarded as the century of biology, the life sciences are undergoing [...]

Published
2004

38. Mouse Biology at Monterotondo

Author

Fotis C. Kafatos

Subjects
European molecular biology laboratory, Internationalization, Multidisciplinary, Member states, General partnership, Library science, Minor (academic), Biology, Conditional mutagenesis
Abstract

Gretchen Vogel's article on the European Molecular Biology Laboratory (EMBL) Programme at Monterotondo (“Institute sparks an Italian Renaissance in mouse biology,” News Focus, 8 Oct., p. 217) was a well-deserved recognition of the success of this new branch of EMBL. Regrettably, the other parties that share credit for the success of Monterotondo were not mentioned. EMBL would not have succeeded if it were the only research entity on the Adriano Buzzati-Traverso campus at Monterotondo. The Consiglio Nazionale della Ricerca (CNR), through its Institute of Cell Biology (IBC) led by Glauco Tocchini-Valentini, has been an essential partner, inviting and hosting EMBL, providing an active scientific environment, sharing space and equipment, and solving a myriad of minor and major problems. CNR-IBC also operates EMMA-Monterotondo (the European Mutant Mouse Archive). Further credit is due to the pioneer teams of Klaus Rajewsky, Walter Witke, and Ulrich Kalinke, who, within strict budgetary constraints, created the nucleus of EMBL-Monterotondo. Rajewsky, the first director, brought conditional mutagenesis to the campus (an approach still central to the research of the EMBL groups), and encouraged the complementary development of powerful, RNA-based methods by IBC. The CNR/EMBL partnership created an atmosphere that justified increased funding by the EMBL member states in 2000, which was essential for the recruitment and success of Nadia Rosenthal and her group leaders. The lessons are of broader significance, too. The important shared goal of EMBL-Monterotondo, to promote internationalization of the Italian research landscape, cannot be achieved unilaterally. The recipe for success includes recruiting outstanding and dedicated staff, but also mutually respectful interaction and fruitful cooperation with local colleagues.

Published
2004
Full Text
View/download PDF

42. Phylogenetic Perspectives in Innate Immunity.

Author

Hoffman, Jules A., Kafatos, Fotis C., Janeway, Jr., Charles A., and Ezekowitz, R.A.B.

Subjects
*NATURAL immunity, *MOLECULAR immunology, *MAMMALS, *DROSOPHILA, *IMMUNOLOGY, *MOLECULES
Abstract

Presents research which studied innate immunity in Drosophila and mammals. Concept of innate immunity; Similarities in innate immunity factors in Drosophila and mammals based on their common ancestry; Role of innate immunity in mammals, especially in relation to adaptive immunity; Mammalian effector molecules; Innate immunity and human disease.

Published
1999

44. Cytodifferentiation during Insect Metamorphosis: The Galea of Silkmoths

Author

Fotis C. Kafatos and Ned Feder

Subjects
DNA Replication, Cellular differentiation, Cocoonase, media_common.quotation_subject, Mitosis, Tritium, Exocrine Glands, Leucine, Botany, Galea, Animals, Metamorphosis, Bombyx, media_common, Multidisciplinary, biology, Lysine, Metamorphosis, Biological, Cell Differentiation, biology.organism_classification, Cell biology, Pupa, Cytoplasm, Protein Biosynthesis, Autoradiography, RNA, Peptide Hydrolases, Thymidine
Abstract

In the galea of silkmoths undergoing metamorphosis, generalized epidermal cells, which had previousty secreted pupal cuticle, transform into highly specialized cells producing a new protein, the enzyme cocoonase. These cells first segregate by mitosis and displacement, then grow rapidly through endomitosis and accumulation of RNA-rich cytoplasm, and finally begin rapid synthesis of cocoonase. Replication of DNA continues in fully differentiated cells synthesizing cocoonase.

Published
1968
Full Text
View/download PDF

45. Cyanogenic Glandular Apparatus of a Millipede

Author

Hans E. Eisner, Jerrold Meinwald, Thomas Eisner, F. C. Kafatos, and J. J. Hurst

Subjects
Mandelonitrile, chemistry.chemical_compound, Multidisciplinary, biology, chemistry, Biochemistry, Cyanide, Chemical factor, Botany, Millipede, biology.organism_classification, Compartment (pharmacokinetics)
Abstract

The cyanogenic secretion of the polydesmoid millipede Apheloria corrugata (Wood) is discharged from paired, serially arranged glands, each consisting of two compartments. In one compartment is stored an undissociated cyanogenic compound, and in the other, a chemical factor that triggers cyanogenesis. The gland is constructed in such a way that the contents of the two compartments are mixed, and cyanogenesis is initiated, at the very instant of discharge. The stored cyanide precursor may be mandelonitrile.

Published
1963
Full Text
View/download PDF

46. Hydra viridis : Inhibition by the Basal Disk of Basal Disk Differentiation

Author

H. K. MacWilliams and Fotis C. Kafatos

Subjects
Cnidaria, Basal (phylogenetics), Multidisciplinary, Cellular differentiation, Regeneration (biology), Animals, Regeneration, Cell Differentiation, Lernaean Hydra, Anatomy, Biology, Feedback
Abstract

When the basal dist of Hydra viridis is excised, a new disk is regenerated. A basal disk grafted on an animal regenerating its own disk can suppress this regeneration. The effect is reversed if the grafted basal disk is subsequently excised. For inhibition to occur, the grafted disk must be present for at least 3 hours, beginning no later than 2 hours after amputation. The results indicate that the basal disk participated in the control of its own differentiation.

Published
1968
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results