Search

Your search keyword '"Dawson, Valina L."' showing total 16 results
Start Over Author "Dawson, Valina L." Journal science
16 results on '"Dawson, Valina L."'

1. Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

Author

Kam, Tae-In, Mao, Xiaobo, Park, Hyejin, Chou, Shih-Ching, Karuppagounder, Senthilkumar S., Umanah, George Essien, Yun, Seung Pil, Brahmachari, Saurav, Panicker, Nikhil, Chen, Rong, Andrabi, Shaida A., Qi, Chen, Poirier, Guy G., Pletnikova, Olga, Troncoso, Juan C., Bekris, Lynn M., Leverenz, James B., Pantelyat, Alexander, Ko, Han Seok, Rosenthal, Liana S., Dawson, Ted M., and Dawson, Valina L.

Published
2018

7. A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

Author

Wang, Yingfei, An, Ran, Umanah, George K., Park, Hyejin, Nambiar, Kalyani, Eacker, Stephen M., Kim, BongWoo, Bao, Lei, Harraz, Maged M., Chang, Calvin, Chen, Rong, Wang, Jennifer E., Kam, Tae-In, Jeong, Jun Seop, Xie, Zhi, Neifert, Stewart, Qian, Jiang, Andrabi, Shaida A., Blackshaw, Seth, Zhu, Heng, Song, Hongjun, Ming, Guo-li, Dawson, Valina L., and Dawson, Ted M.

Published
2016

8. Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3

Author

Mao, Xiaobo, Ou, Michael Tianhao, Karuppagounder, Senthilkumar S., Kam, Tae-In, Yin, Xiling, Xiong, Yulan, Ge, Preston, Umanah, George Essien, Brahmachari, Saurav, Shin, Joo-Ho, Kang, Ho Chul, Zhang, Jianmin, Xu, Jinchong, Chen, Rong, Park, Hyejin, Andrabi, Shaida A., Kang, Sung Ung, Gonçalves, Rafaella Araújo, Liang, Yu, Zhang, Shu, Qi, Chen, Lam, Sharon, Keiler, James A., Tyson, Joel, Kim, Donghoon, Panicker, Nikhil, Yun, Seung Pil, Workman, Creg J., Vignali, Dario A. A., Dawson, Valina L., Ko, Han Seok, and Dawson, Ted M.

Published
2016

9. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

Author

Chung, Kenny K.K., Thomas, Bobby, Li, Xiaojie, Pletnikova, Olga, Troncoso, Juan C., Marsh, Laura, Dawson, Valina L., and Dawson, Ted M.

Subjects
Nervous system -- Degeneration, Parkinson's disease -- Research, Science and technology, Research
Abstract

Parkin is an E3 ubiquitin ligase involved in the ubiquitination of proteins that are important in the survival of dopamine neurons in Parkinson's disease (PD). We show that parkin is S-nitrosylated in vitro, as well as in five in a mouse model of PD and in brains of patients with PD and diffuse Lewy body disease. Moreover, S-nitrosylation inhibits parkin's ubiquitin E3 ligase activity and its protective function. The inhibition of parkin's ubiquitin E3 ligase activity by 5-nitrosylation could contribute to the degenerative process in these disorders by impairing the ubiquitination of parkin substrates., Parkinson's disease (PD) is a common neurodegenerative disorder that leads to the progressive loss of dopamine (DA) neurons (1). The majority of PD is sporadic and is thought to be [...]

Published
2004

13. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity

Author

Dawson, Valina L., Dawson, Ted M., and Snyder, Solomon H.

Subjects
Neurotoxic agents -- Physiological aspects, Nitric acid -- Physiological aspects, Science and technology, Physiological aspects
Abstract

Poly(adenosine 5'-diphosphoribose) synthetase (PARS) is a nuclear enzyme which, when activated by DNA strand breaks, adds up to 100 adenosine 5'-diphosphoribose (ADP-ribose) units to nuclear proteins such as histones and PARS itself. This activation can lead to cell death through depletion of β-nicotinamide adenine dinucleotide (the source of ADP-ribose) and adenosine triphosphate. Nitric oxide (NO) stimulated ADP-ribosylation of PARS in rat brain. Benzamide and other derivatives, which inhibit PARS, blocked N-methyl-D-aspartate NO-mediated neurotoxicity with relative potencies paralleling their ability to inhibit PARS. Thus, NO appeared to elicit neurotoxicity by activating PARS., Nitric oxide is a messenger molecule that regulates macrophage killing of tumor cells and bacteria (1) and blood vessel relaxation (2) and also is a neurotransmitter (3). When produced in [...]

Published
1994

15. Response.

Author

Chung, Kenny K. K., Dawson, Valina L., and Dawson, Ted M.

Subjects
*LETTERS to the editor, *NITRIC oxide
Abstract

Presents reply to a letter about concentration of nitric oxide in human body.

Published
2004

16. S-Nitrosylation of Parkin Regulates Ubiquitination andCompromises Parkin's Protective Function.

Author

Chung, Kenny K. K., Thomas, Bobby, Li, Xiaojie, Pletnikova, Olga, Troncoso, Juan C., Marsh, Laura, Dawson, Valina L., and Dawson, Ted M.

Subjects
*PROTEINS, *BIOMOLECULES, *PARKINSON'S disease, *NEURONS, *CELLS, *EXTRAPYRAMIDAL disorders
Abstract

Parkin is an E3 ubiquitin ligase involved in the ubiquitination of proteins that are important in the survival of dopamine neurons in Parkinson's disease (PD). We show that parkin is S-nitrosylated in vitro, as well as in vivo in a mouse model of PD and in brains of patients with PD and diffuse Lewy body disease. Moreover, S-nitrosylation inhibits parkin's ubiquitin E3 ligase activity and its protective function. The inhibition of parkin's ubiquitin E3 ligase activity by S-nitrosylation could contribute to the degenerative process in these disorders by impairing the ubiquitination of parkin substrates. [ABSTRACT FROM AUTHOR]

Published
2004
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results