Search

Your search keyword '"Castle, A."' showing total 314 results
Start Over Author "Castle, A." Journal science
314 results on '"Castle, A."'

3. A Gene Map of the Human Genome

Author

Schuler, G. D., Boguski, M. S., Stewart, E. A., Stein, L. D., Gyapay, G., Rice, K., White, R. E., Rodriguez-Tomé, P., Aggarwal, A., Bajorek, E., Bentolila, S., Birren, B. B., Butler, A., Castle, A. B., Chiannilkulchai, N., Chu, A., Clee, C., Cowles, S., Day, P. J. R., Dibling, T., Drouot, N., Dunham, I., Duprat, S., East, C., Edwards, C., Fang, N., Fizames, C., Garrett, C., Green, L., Hadley, D., Harris, M., Harrison, P., Brady, S., Hicks, A., Holloway, E., Hui, L., Hussain, S., Ma, J., MacGilvery, A., Mader, C., Maratukulam, A., Matise, T. C., McKusick, K. B., Morissette, J., Mungall, A., Muselet, D., Nusbaum, H. C., Page, D. C., Peck, A., Perkins, S., Piercy, M., Qin, F., Quackenbush, J., Ranby, S., Reif, T., Rozen, S., Sanders, C., She, X., Silva, J., Slonim, D. K., Soderlund, C., Tabar, P., Thangarajah, T., Vega-Czarny, N., Vollrath, D., Voyticky, S., Wilmer, T., Wu, X., Adams, M. D., Aufiray, C., Walter, N. A. R., Brandon, R., Dehejia, A., Goodfellow, P. N., Houlgatte, R., Hudson, J. R., Ide, S. E., Iorio, K. R., Lee, W. Y., Seki, N., Nagase, T., Ishikawa, K., Nomura, N., Phillips, C., Polymeropoulos, M. H., Sandusky, M., Schmitt, K., Berry, R., Swanson, K., Torres, R., Venter, J. C., Sikela, J. M., Beckmann, J. S., Weissenbach, J., Myers, R. M., Cox, D. R., James, M. R., Bentley, D., Deloukas, P., Lander, E. S., and Hudson, T. J.

Published
1996

4. Genome Maps 7: The Human Transcript Map

Author

Jasny, Barbara R., Schuler, G. D., Boguski, M. S., Hudson, T. J., Hui, L., Ma, J., Castle, A. B., Wu, X., Silva, J., Nusbaum, H. C., Birren, B. B., Slonim, D. K., Rozen, S., Stein, L. D., Page, D., Lander, E. S., Stewart, E. A., Aggarwal, A., Bajorek, E., Brady, S., Chu, A., Fang, N., Hadley, D., Harris, M., Hussain, S., Maratukulam, A., Perkins, S., Piercy, M., Qin, F., Reif, T., Sanders, C., She, X., Sun, W. L., Tabar, P., Voyticky, S., Mader, C., McKusick, K. B., Fan, J. B., Cowles, S., Quackenbush, J., Vollrath, D., Myers, R. M., Cox, D. R., Butler, A., Clee, C., Dibling, T., East, C., Edwards, C., Garrett, C., Green, L., Harrison, P., Hicks, A., Holloway, E., Ranby, S., MacGilvery, A., Mungall, A., Peck, A., Wilmer, T., Soderlund, C., Rice, K., Dunham, I., Bentley, D., Deloukas, P., Gyapay, G., Chiannilkulchai, N., Fizames, C., Bentolila, S., Duprat, S., Vega-Czarny, N., Muselet, D., Drouot, N., Morissette, J., Beckmann, J., Weissenbach., J., James, M. R., White, R. E., Thangarajah, T., Day, P. J. R., Goodfellow, P. N., Schmitt, K., Walter, N. A. R., Berry, R., Iorio, K. R., Sikela, J. M., Polymeropoulos, M. H., Torres, R., Ide, S. S. E., Dehejia, A., Houlgatte, R., Auffray, C., Adams, M. D., Phillips, C., Brandon, R., Sandusky, M., Venter, J. C., Seki, N., Nagase, T., Ishikawa, K., Nomura, N., Rodriguez-Tome, P., Matise, T. C., Lee, W. Y., Swanson, K. A., and Hudson, J. R.

Published
1996

5. A Physical Map of 30,000 Human Genes

Author

Deloukas, P., Schuler, G. D., Gyapay, G., Beasley, E. M., Soderlund, C., Rodriguez-Tomé, P., Hui, L., Matise, T. C., McKusick, K. B., Beckmann, J. S., Bentolila, S., Birren, B. B., Browne, J., Butler, A., Castle, A. B., Chiannilkulchai, N., Clee, C., Day, P. J. R., Dehejia, A., Dibling, T., Drouot, N., Duprat, S., Fizames, C., Fox, S., Gelling, S., Green, L., Harrison, P., Hocking, R., Holloway, E., Hunt, S., Keil, S., Lijnzaad, P., Ma, J., Mendis, A., Miller, J., Morissette, J., Muselet, D., Nusbaum, H. C., Peck, A., Rozen, S., Simon, D., Slonim, D. K., Staples, R., Stein, L. D., Stewart, E. A., Suchard, M. A., Thangarajah, T., Vega-Czarny, N., Webber, C., Wu, X., Hudson, J., Auffray, C., Nomura, N., Sikela, J. M., Polymeropoulous, M. H., James, M. R., Lander, E. S., Hudson, T. J., Myers, R. M., Cox, D. R., Weissenbach, J., Boguski, M. S., and Bentley, D. R.

Published
1998

7. An STS-Based Map of the Human Genome

Author

Hudson, Thomas J., Stein, Lincoln D., Gerety, Sebastian S., Ma, Junli, Castle, Andrew B., Silva, James, Slonim, Donna K., Baptista, Rafael, Kruglyak, Leonid, Xu, Shu-Hua, Hu, Xintong, Rosenberg, Carl, Reeve-Daly, Mary Pat, Rozen, Steve, Hui, Lester, Wu, Xiaoyun, Vestergaard, Christina, Wilson, Kimberly M., Bae, Jane S., Maitra, Shanak, Ganiatsas, Soula, Evans, Cheryl A., DeAngelis, Margaret M., Ingalls, Kimberly A., Nahf, Robert W., Horton, Lloyd T., Anderson, Michele Oskin, Collymore, Alville J., Ye, Wenjuan, Kouyoumjian, Vardouhie, Zemsteva, Irena S., Tam, James, Devine, Richard, Courtney, Dorothy F., Renaud, Michelle Turner, Nguyen, Huy, O'Connor, Tara J., Fizames, Cécile, Fauré, Sabine, Gyapay, Gabor, Dib, Colette, Morissette, Jean, Orlin, James B., Birren, Bruce W., Goodman, Nathan, Weissenbach, Jean, Hawkins, Trevor L., Foote, Simon, Page, David C., and Lander, Eric S.

Published
1995

25. Brine-driven destruction of clay minerals in Gale crater, Mars

Author

Bristow, T. F., primary, Grotzinger, J. P., additional, Rampe, E. B., additional, Cuadros, J., additional, Chipera, S. J., additional, Downs, G. W., additional, Fedo, C. M., additional, Frydenvang, J., additional, McAdam, A. C., additional, Morris, R. V., additional, Achilles, C. N., additional, Blake, D. F., additional, Castle, N., additional, Craig, P., additional, Des Marais, D. J., additional, Downs, R. T., additional, Hazen, R. M., additional, Ming, D. W., additional, Morrison, S. M., additional, Thorpe, M. T., additional, Treiman, A. H., additional, Tu, V., additional, Vaniman, D. T., additional, Yen, A. S., additional, Gellert, R., additional, Mahaffy, P. R., additional, Wiens, R. C., additional, Bryk, A. B., additional, Bennett, K. A., additional, Fox, V. K., additional, Millken, R. E., additional, Fraeman, A. A., additional, and Vasavada, A. R., additional

Published
2021
Full Text
View/download PDF

37. Discovery and Directed Evolution of a Glyphosate Tolerance Gene

Author

Michael Lassner, Yong Hong Chen, Rebecca Gorton, Donglong Liu, Nicholas B. Duck, Hyeon-Je Cho, Linda A. Castle, Phillip A. Patten, Daniel L. Siehl, James F. Johnston Wong, and Sean M. Bertain

Subjects
Molecular Sequence Data, Drug Resistance, Glycine, Bacillus, Biology, medicine.disease_cause, Zea mays, Catalysis, chemistry.chemical_compound, Transformation, Genetic, Acetyltransferases, Arabidopsis, Tobacco, Botany, Escherichia coli, medicine, Amino Acid Sequence, Gene, Gene Library, Recombination, Genetic, Multidisciplinary, Herbicides, Genetic Variation, Acetylation, DNA Shuffling, Plants, Genetically Modified, Directed evolution, biology.organism_classification, Recombinant Proteins, DNA shuffling, Genetically modified organism, Kinetics, Transformation (genetics), Biochemistry, chemistry, Mutagenesis, Glyphosate, Directed Molecular Evolution
Abstract

The herbicide glyphosate is effectively detoxified by N -acetylation. We screened a collection of microbial isolates and discovered enzymes exhibiting glyphosate N -acetyltransferase (GAT) activity. Kinetic properties of the discovered enzymes were insufficient to confer glyphosate tolerance to transgenic organisms. Eleven iterations of DNA shuffling improved enzyme efficiency by nearly four orders of magnitude from 0.87 mM –1 min –1 to 8320 mM –1 min –1 . From the fifth iteration and beyond, GAT enzymes conferred increasing glyphosate tolerance to Escherichia coli, Arabidopsis , tobacco, and maize. Glyphosate acetylation provides an alternative strategy for supporting glyphosate use on crops.

Published
2004
Full Text
View/download PDF

38. Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction Microarrays

Author

Daniel D. Shoemaker, John C. Castle, Zhengyan Kan, Jason M. Johnson, Roland Stoughton, Patrick M. Loerch, Christopher D. Armour, Philip W. Garrett-engele, Eric E. Schadt, and Ralph Santos

Subjects
DNA, Complementary, Molecular Sequence Data, Exonic splicing enhancer, Computational biology, Biology, Genome, Cell Line, Amyloid beta-Protein Precursor, Exon, RNA Precursors, Humans, Protein Isoforms, Tissue Distribution, Gene, Oligonucleotide Array Sequence Analysis, Expressed Sequence Tags, Genetics, Multidisciplinary, Genome, Human, Reverse Transcriptase Polymerase Chain Reaction, Alternative splicing, Proteins, Exons, Phosphoric Monoester Hydrolases, Alternative Splicing, ROC Curve, RNA splicing, Hydroxymethylglutaryl CoA Reductases, Human genome, DNA microarray
Abstract

Alternative pre–messenger RNA (pre-mRNA) splicing plays important roles in development, physiology, and disease, and more than half of human genes are alternatively spliced. To understand the biological roles and regulation of alternative splicing across different tissues and stages of development, systematic methods are needed. Here, we demonstrate the use of microarrays to monitor splicing at every exon-exon junction in more than 10,000 multi-exon human genes in 52 tissues and cell lines. These genome-wide data provide experimental evidence and tissue distributions for thousands of known and novel alternative splicing events. Adding to previous studies, the results indicate that at least 74% of human multi-exon genes are alternatively spliced.

Published
2003
Full Text
View/download PDF

39. A Gene Map of the Human Genome

Author

Christopher Mader, B. B. Birren, Jean Morissette, C. Sanders, K. Swanson, Xiao-Yu Wu, Thomas J. Hudson, Mark S. Boguski, A. Maratukulam, Midori A. Harris, L. Green, S. Hussain, C. East, Robert E. White, Andrew A. Hicks, K. R. Iorio, Andrew B. Castle, W.-L. Sun, Paul Harrison, Simone Duprat, Kate Rice, Eric S. Lander, X. She, Shanti M. Perkins, Ammon B. Peck, Mina Sandusky, John Quackenbush, L. Hui, David Bentley, K. B. McKusick, Anindya Dehejia, Gregory D. Schuler, Gabor Gyapay, T. Dibling, C M Clee, Amita Aggarwal, James R. Hudson, R. Torres, Eva Bajorek, Peter N. Goodfellow, Mark Piercy, Mark Raymond Adams, Jun Fan, Cheryl Phillips, Elizabeth A. Stewart, Nicole Y. Fang, N. Drouot, Ian Dunham, Donna K. Slonim, Mihael H. Polymeropoulos, N. Nomura, Andrew J. Mungall, K. Ishikawa, E. Holloway, J. Ma, P. J. R. Day, N. Seki, S. Bentolila, Jean Weissenbach, P. Rodriguez-Tomé, Adam Butler, Sid Cowles, Angela M. Chu, Karin Schmitt, R. Houlgatte, Panos Deloukas, Tim Reif, Michael R. James, C. Louis-Dit-Sully, S. Voyticky, P. Tabar, David R. Cox, A. MacGilvery, David C. Page, Carol Soderlund, C A Edwards, S A Ranby, Nicole A.R. Walter, Douglas Vollrath, T. E. Wilmer, Lincoln Stein, H. C. Nusbaum, Takahiro Nagase, Tara C. Matise, T. Thangarajah, Susan E. Ide, Fawn Qin, Richard M. Myers, Steve Rozen, Jacques S. Beckmann, Richard Berry, James M. Sikela, Charles Auffray, Shannon T. Brady, Cécile Fizames, Christine Garrett, David Hadley, Delphine Muselet, Nathalie Vega-Czarny, Rhonda Brandon, Wha‐Young Lee, N. Chiannilkulchai, J. C. Venter, and James Silva

Subjects
Sequence-tagged site, Yeast artificial chromosome, Genetics, Expressed sequence tag, Multidisciplinary, Gene map, Gene mapping, Human genome, Computational biology, Genome project, Biology, Genome
Abstract

The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. The integrated resource is available through a site on the World Wide Web at http://www.ncbi.nlm.nih.gov/SCIENCE96/.

Published
1996
Full Text
View/download PDF

40. Aseismic Uplift in California

Author

Castle, Robert O., Elliott, Michael R., Gilmore, Thomas D., Mark, Robert K., Newman, Evelyn B., Tinsley, John C., Jackson, David D., Lee, Wook B., and Liu, Chi-Ching

Published
1981

Catalog

Books, media, physical & digital resources
See catalog results