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Intracellular Accumulation of T-Cell Receptor Complex Molecules in a Human T-Cell Line This work was aimed at understanding the mechanisms of T-lymphocyte function by studying the cellular distribution and traffic [...]

Heat shock genes are activated when a cell responds to stress, such as an increase in temperature (37 [deg.] to 42 [deg.]C) or exposure to inhibitors of oxidative phosphorylation (1). [...]

Chromosomes of four species of Leishmania represented by ten different geographic isolates were analyzed by pulsed field gradient gel electrophoresis (PFG) to assess chromosome stability in these parasitic protozoans. Among different geographic isolates of the same subspecies, more than two-thirds of chromosomes had similar sizes, ethidium bromide staining intensities, and locations of α,β-tubulin genes. However, among New World Leishmania, members of different species or subspecies have fewer than one-third of their chromosomes in common. Therefore, PFG karyotypes of Leisimania exhibit intraspecific variability similar to that reported for other parasitic protozoans. The greater similarities ofthe karyotypes of members of the same Leishmania subspecies may indicate that they represent valid taxa. These similarities also allowed the use of PFG in clinical diagnosis for rapid and accurate tiping of patient isolates. [ABSTRACT FROM AUTHOR]