1. Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events
- Author
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David C. Hooper, Anthony A. Philippakis, Jessie M. Gaeta, Sinéad B. Chapman, Christopher Tomkins-Tinch, Caroline N. Cusick, Matthew R. Bauer, John A. Branda, Steven K. Reilly, Lawrence C. Madoff, Kim A. Lagerborg, Stephen F. Schaffner, Molly Kemball, Timelia Fink, Bronwyn MacInnis, Melissa Rudy, Damien Slater, Jeremy Luban, Daniel J. Park, Jacob E. Lemieux, Edward T. Ryan, William P. Hanage, Melis N. Anahtar, Andreas Gnirke, Sushma Chaluvadi, Felecia Cerrato, Adrianne Gladden-Young, Katelyn Flowers, James J. O’Connell, Anna Neumann, Tami D. Lieberman, Eric S. Rosenberg, Catherine M. Brown, Cameron Myhrvold, Bennett M. Shaw, Erica Normandin, Katherine C. DeRuff, Katherine J. Siddle, Jason B. Harris, Sarah E Turbett, Glen R. Gallagher, Travis P. Baggett, Christine Loreth, Pardis C. Sabeti, Virginia M. Pierce, Lydia A. Krasilnikova, Sandra Smole, Amber Carter, Maha R. Farhat, Regina C. LaRocque, Meagan Burns, Aaron E. Lin, and Gordon Adams
- Subjects
0301 basic medicine ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Genome, Viral ,law.invention ,Disease Outbreaks ,03 medical and health sciences ,0302 clinical medicine ,law ,Vulnerable population ,Humans ,030212 general & internal medicine ,Phylogeny ,Multidisciplinary ,Phylogenetic tree ,Extramural ,SARS-CoV-2 ,COVID-19 ,030104 developmental biology ,Transmission (mechanics) ,Geography ,Evolutionary biology ,Epidemiological Monitoring ,Skilled Nursing Facility ,Boston - Abstract
Phylogenetics of superspreading One important characteristic of coronavirus epidemiology is the occurrence of superspreading events. These are marked by a disproportionate number of cases originating from often-times asymptomatic individuals. Using a rich sequence dataset from the early stages of the Boston outbreak, Lemieux et al. identified superspreading events in specific settings and analyzed them phylogenetically (see the Perspective by Alizon). Using ancestral trait inference, the authors identified several importation events, further investigated the context and contribution of particular superspreading events to the establishment of local and wider SARS-CoV-2 transmission, and used viral phylogenies to describe sustained transmission. Science , this issue p. eabe3261 ; see also p. 574
- Published
- 2020
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