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7. Cancer cell necrosis by autoschizis: Synergism of antitumor activity of vitamin C: Vitamin K3on human bladder carcinoma T24 cells

Author

Gilloteaux, J., Jamison, J. M., Arnold, D., Ervin, E., Eckroat, L., Docherty, J. J., Neal, D., and Summers, J. L.

Abstract

Scanning and transmission electron microscopy and fluorescence light microscopy were employed to characterize the cytotoxic effects of vitamin C (VitC), vitamin K3(VitK3) or a VitC:VK3combination on a human bladder carcinoma cell line (T24) following 1‐h and 2‐h vitamin treatment. T24 cells exposed to VitC alone exhibited membranous damage (blebs and endoplasmic extrusions, elongated microvilli). VitK3‐treated cells displayed greater membrane damage and enucleation than those treated with VitC as well as cytoplasmic defects characteristic of cytoskeletal damage. VitC:VitK3‐treated cells showed exaggerated membrane damage and an enucleation process in which the perikarya separate from the main cytoplasmic cell body by self‐excision. Self‐excisions continued for perikarya which contained an intact nucleus surrounded by damaged organelles. After further excisions of cytoplasm, the nuclei exhibited nucleolar segregation and chromatin decondensation followed by nuclear karryorhexis and karyolysis. This process of cell death induced by oxidative stress was named autoschizis because it showed both apoptotic and necrotic morphologic characteristics.

Published
1998
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8. Characterization of the early events in vitamin C and K3-induced death of human bladder tumor cells.

Author

Ervin E, Jamison JM, Gilloteaux J, Docherty JJ, Jasso J, and Summers JL

Subjects
Ascorbic Acid administration & dosage, Ascorbic Acid pharmacology, Carcinoma ultrastructure, Drug Synergism, Humans, Microscopy, Electron methods, Microscopy, Electron, Scanning methods, Time Factors, Tumor Cells, Cultured drug effects, Urinary Bladder Neoplasms ultrastructure, Vitamin K 1 administration & dosage, Vitamin K 1 pharmacology, Antineoplastic Combined Chemotherapy Protocols pharmacology, Carcinoma drug therapy, Cell Death drug effects, Urinary Bladder Neoplasms drug therapy
Published
1998

9. Scanning electron microscopy and transmission electron microscopy aspects of the synergistic antitumor activity of vitamin C/vitamin K3 combinations against human T24 bladder carcinoma: another kind of cell death?

Author

Gilloteaux J, Jamison JM, Ervin E, Arnold D, and Summers JL

Subjects
Ascorbic Acid administration & dosage, Ascorbic Acid pharmacology, Carcinoma ultrastructure, Cell Death, Humans, Microscopy, Electron methods, Microscopy, Electron, Scanning methods, Tumor Cells, Cultured drug effects, Urinary Bladder Neoplasms ultrastructure, Vitamin K 1 administration & dosage, Vitamin K 1 pharmacology, Antineoplastic Combined Chemotherapy Protocols pharmacology, Carcinoma drug therapy, Urinary Bladder Neoplasms drug therapy
Published
1998

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