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Objectives: To evaluated Fetuin-A levels of patients admitted in the intensive care unit with a diagnosis of sepsis. Methods : This study was conducted at the Faculty of Medicine, Canakkale Onsekiz Mart University Hospital, Canakkal, Turkey, between February 2015 and October 2015. Forty septic patients were included in the study. Subsequent to clinical suspicion of sepsis, serum levels of C-reactive protein (CRP) and procalcitonin; and white blood cell (WBC) counts were evaluated at 3 time-points: 0 (basal), 24, and 72 hours. Results : The mean Fetuin-A levels at the 3 time-points were 58.5 ± 29.2 ng/mL, 40.9 ± 23.6 ng/mL, and 47.8 ± 25.7 ng/mL, respectively. Fetuin-A levels at 24 hours were significantly lower than the basal level ( p greater than 0.05), where as no significant difference was observed between the basal levels and those at 72 hours ( p greater than 0.05). Correlation between the temporal changes in Fetuin-A levels and the changes in other inflammatory markers (CRP, procalcitonin and WBC) was examined. Fetuin A was found to have only a negative correlation with serum procalcitonin level ( p less than 0.05). Conclusion : In this study, serum Fetuin-A levels in septic patients decreased significantly in the first 24 hours, followed by an insignificant increase at 72 hours. These findings suggest that monitoring of Fetuin-A levels may help predict the time of occurrence of sepsis and prognosis of sepsis. Saudi Med J 2018; Vol. 39 (7): 679-684 doi: 10.15537/smj.2018.7.22418 How to cite this article: Altinisik HB, Altinisik U, Uysal S, Sacar S, Simsek T, Demiraran Y.Are Fetuin-A levels beneficial for estimating timing of sepsis occurrence? Saudi Med J . 2018 Jul;39(7):679-684. doi: 10.15537/smj.2018.7.22418.