1. Role of anticoagulation in lowering the mortality in hospitalized covid-19 patients
- Author
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Muhammad, Aamir Waheed, Khalid, Rashid, Tawfik, Rajab, Ahmad, Rajab, Adnan H, Adnan, Harris, Fayyaz, Ahmad A, Ibad, Rabia, Basri, Yahya, Khan, Habib I, Alhabib, and Abdelnaser, Elzouki
- Subjects
SARS-CoV-2 ,Thromboembolism ,Anticoagulants ,Humans ,Venous Thromboembolism ,General Medicine ,Blood Coagulation ,COVID-19 Drug Treatment - Abstract
To reducing the risk of venous thromboembolic (VTE) events and subsequent mortality in covid-19 patients is still a matter of research. This systematic review and meta-analysis serve the purpose of comparing the mortality associated with the intensity of anticoagulation in patients admitted with covid-19.A total of 7120 patients were recruited in 11 studies comparing using prophylactic anticoagulants against therapeutic anticoagulants.Our study showed that using prophylactic anticoagulants was associated with a 42% reduction in mortality compared to therapeutic anticoagulants (OR 0.58 (95% CI:0.676-0.499),Our meta-analysis favors using prophylactic anticoagulation in covid-19 patients reduces all-cause mortality in comparison to therapeutic anticoagulation however the impact on mortality when compared with no anticoagulation was not significant.PROSPERO Number: CRD42021257320.
- Published
- 2022
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