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The article presents a study which aims to examine how an alkaloid sequestration protect the green poison frog from predator attacks in Isla Taboga, Panama in 2010. Physalaemus pustulosus, a non-toxic frog, and Dendrobates auratus, an alkaloid-sequestering frog, were offered as prey to Sericopelma rubnitens, a theraphosid spider. The study reveals that an alkaloid sequestration did not prevent D. auratus from attacks, but did lessen the risk to be eaten. It shows that spiders are one of just a few recorded D. auratus predators in Taboga and might represent a strong inclusive force for Taboga's high toxicity.