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Alkylation of 9-methylthio-nido-carborane under the action of the corresponding iodo derivatives of alanine and homoalanine furnished new (nido-carboran-9-yl) derivatives of (R)-cysteine and (S)-methionine. The synthesized chiral nido-carborane derivatives contain asymmetric carbon and sulfur atoms, as well as a chiral plane. The developed approach to the synthesis of sulfur-containing B(9)-substituted nido-carborane derivatives can be used in the preparation of bioactive compounds, including potential boron delivery agents for boron neutron capture therapy of oncological diseases. [ABSTRACT FROM AUTHOR]

Synthesis of new nido-carborane-containing 6-thiopurines and thioguanines based on nucleophilic substitution of the chlorine atom in the specially synthesized chloroacetyl derivative of 3-amino-nido-carborane by the action of 6-thiopurine or thioguanine in the presence of sodium hydride in ethanol was developed. The resulting 6-thiopurine derivatives containing a nido-carborane moiety and unsubstituted at the position 9 are of interest as potential biologically active compounds, boron delivery agents to tumor cells, and as the basis for nido-carborane-containing nucleosides. [ABSTRACT FROM AUTHOR]

A series of novel derivatives of d-biotin containing closo- and nido-carborane residues bound to the biotin carbonyl group either directly or via a linker were synthesized. The possibility of synthesizing a d-biotin conjugate containing two closo-carborane moieties and a glutamic acid residue was shown. The obtained compounds are of interest for biological testing as potential boron delivery agents for the boron neutron capture therapy of tumors. [ABSTRACT FROM AUTHOR]