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The purpose of the study: is to establish the characteristics of the development of endogenous intoxication during experimental obstruction of the urinary tract. Materials and methods: to achieve this goal, one control and three experimental groups of animals were formed, in which blood was taken from the marginal ear vein on the 3rd, 7th, 14th and 21st day of the experiment. The following parameters were determined in blood serum: urea, creatinine, total protein and albumin. The level of endogenous intoxication was assessed by the indicators of medium-mass molecules, circulating immune complexes and malon dialdehyde. Results: statistical analysis of blood biochemical parameters and endogenous intoxication markers confirm the link between modern biomarkers of renal injury and morphological changes in the tissues of obstructive and compensatory organs. Conclusion: our findings point to the overstress adaptation mechanisms, the development of oxidative stress and exhibit a high level of endogenous intoxication, resulting in structural and metabolic changes in the affected and in the contralateral kidney.