42 results
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2. Contents list.
3. De novo design of a stapled peptide targeting SARS-CoV-2 spike protein receptor-binding domain.
4. Druggable targets for the immunopathy of Alzheimer's disease.
5. Progress in the discovery and development of small molecule methuosis inducers.
6. Contents list.
7. Antibacterial activities of anthraquinones: structure–activity relationships and action mechanisms.
8. Bioorthogonal activation of prodrugs, for the potential treatment of breast cancer, using the Staudinger reaction.
9. The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models.
10. Contents list.
11. Anti-proliferative activity of nitroquinolone fused acylhydrazones as non-small cell human lung cancer agents.
12. Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.
13. Silver N-heterocyclic carbene complexes are potent uncompetitive inhibitors of the papain-like protease with antiviral activity against SARS-CoV-2.
14. Medicinal chemistry approaches to target the MNK–eIF4E axis in cancer.
15. Polysaccharides from marine biological resources and their anticancer activity on breast cancer.
16. Contents list.
17. Analytical insights into the detoxification process and characterization of a traditional metallopharmaceutical formulation.
18. Novel pirfenidone derivatives: synthesis and biological evaluation.
19. Synthesis of tryptanthrin appended dispiropyrrolidine oxindoles and their antibacterial evaluation.
20. Improving binding entropy by higher ligand symmetry? – A case study with human matriptase.
21. Ferrocene modified analogues of imatinib and nilotinib as potent anti-cancer agents.
22. Contents list.
23. Biological evaluation of novel amidino substituted coumarin-benzazole hybrids as promising therapeutic agents.
24. Discovery of novel tubulin CBSI ( R )-9k from the indanone scaffold for the treatment of colorectal cancer.
25. Pharmacological overview of hederagenin and its derivatives.
26. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action.
27. Pyrazole-containing pharmaceuticals: target, pharmacological activity, and their SAR studies.
28. Design and synthesis of bile acid derivatives and their activity against colon cancer.
29. Synthesis and in vitro anticancer evaluation of novel flavonoid-based amide derivatives as regulators of the PI3K/AKT signal pathway for TNBC treatment.
30. Structure-based discovery of potent inhibitors of Axl: design, synthesis, and biological evaluation.
31. 4-Aminopyrazolopyrimidine scaffold and its deformation in the design of tyrosine and serine/threonine kinase inhibitors in medicinal chemistry.
32. Inhibition of MARK4 by serotonin as an attractive therapeutic approach to combat Alzheimer's disease and neuroinflammation.
33. Synthesis and structure-activity relationships of pirfenidone derivatives as anti-fibrosis agents in vitro .
34. Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics.
35. Recent advances in the discovery of protein tyrosine phosphatase SHP2 inhibitors.
36. Potency and metabolic stability: a molecular hybrid case in the design of novel PF74-like small molecules targeting HIV-1 capsid protein.
37. Nitrile-containing pharmaceuticals: target, mechanism of action, and their SAR studies.
38. Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype.
39. The development of HEC-866 and its analogues for the treatment of idiopathic pulmonary fibrosis.
40. Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties.
41. Identification of 6-amino-1 H -pyrazolo[3,4- d ]pyrimidines with in vivo efficacy against visceral leishmaniasis.
42. Discovery of a novel kinase hinge binder fragment by dynamic undocking.
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