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In recent years, more and more attention has been paid to optical temperature sensing, and how to improve its accuracy is the most important issue. Herein, a new temperature sensing material, SrGd 2 Al 2 O 7 :Bi 3+ ,Mn 4+ , based on fluorescence intensity ratio was designed in this work. It has both blue-purple and red luminescence under 300 nm excitation, and the dual-emitting centers with distinct colors, the different thermal sensitivities of Bi 3+ and Mn 4+ , and the energy transfer between Bi 3+ and Mn 4+ give it excellent signal resolution and accurate temperature detection. The S a of SrGd 2 Al 2 O 7 :0.04Bi 3+ phosphor reaches a maximum value of 8.573% K 4+ at 473 K, and the corresponding -1 is 1.927% K S r is 1.927% K -1 , both of which are significantly better than those of most other reported optical temperature sensing materials. Taking all the results into account, the SrGd 2 Al 2 O 7 :0.04Bi 3+ ,0.003Mn 4+ phosphor can be regarded as a prominent FIR-type temperature sensing material., Competing Interests: On behalf of all authors, the corresponding author states that there is no conflict of interest which could have appeared to influence the work reported in this paper., (This journal is © The Royal Society of Chemistry.)

Aflatoxin B1 (AFB 1 ) is considered as the most prevalent and toxic mycotoxin in food, and is the indispensable index in the monitoring of Pixian Douban , a traditional chinese fermented bean paste from Sichuan. However, the effeciency of AFB 1 detection in Pixian Douban is influenced by the traditional extraction, which is usually complex and time consuming. Therefore, an aptamer-based magnetic solid-phase extraction method was designed for the pretreatment of AFB 1 in this sample, for which Fe 3 O 4 was synthesized via the solvothermal method and then a Fe 3 O 4 @SiO 2 -NH 2 with a core-shell structure was prepared, followed by an AFB 1 -aptamer attachment. The validation was performed via an enzyme-linked immunosorbent assay and compared with HPLC-MS/MS. The linearity range of this method was 0.5-2.0 ng mL -1 with R 2 of 0.981, and recoveries of AFB 1 ranged from 80.19% to 113.92% with RSDs below 7.28% with no significant differences compared to HPLC-MS/MS. The three-time reusability efficiencies of aptamer-MNPs were averaged at 78.24%. The results proved that aptamer-MNPs were high-performance adsorbents for extracting and enriching AFB 1 , facilitating quick and effective detection of AFB 1 in Pixian DouBan samples., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

UV light-triggered trans -to- cis isomerization of azobenzene usually results in the collapse of a self-assembly system owing to the breaking of molecular planarity. Interestingly, two totally opposite self-assembly trends have been detected when a C 2v -symmetric chiral gelator was irradiated by a circularly polarized light (CPL) with specific handedness, indicating that CPL could become a powerful tool in modulating the assembly behaviour of the photo-responsive system., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Treating colorectal cancer (CRC) continues to be a clinical challenge. Coptisine, an alkaloid derived from Coptis chinensis Franch. shows toxic effects on CRC cells, but its underlying mechanism remains elusive. MFG-E8 is involved in tumor growth and progression. Herein, we evaluated the effects of coptisine on MFG-E8 in CRC, and explored the mechanism. The expression of MFG-E8 in CRC and adjacent normal colon tissue samples from patients was detected. The effects of coptisine on CRC cells HCT116 in vitro were evaluated by CCK-8, adhesion and transwell assays. A xenograft tumor model was used to assess the effects of coptisine in vivo . The morphology of CRC tissue was observed by HE staining. Cell signaling was tested using western blotting and immunohistochemical assay. The expression of MFG-E8 in human CRC tissue samples significantly increased compared with that of adjacent normal ones. Coptisine significantly reduced the expressions of MFG-E8 in HCT116 cells and tumor-bearing mice. Moreover, coptisine suppressed the growth, adhesion and metastasis of CRC cells. Coptisine also suppressed the expression of MMP-2 and MMP-9 via the PI3K/AKT signaling pathway. Furthermore, it inhibited epithelial-mesenchymal transition in vivo and in vitro . Coptisine inhibited CRC growth and progression by down-regulating MFG-E8, and is a potential candidate for treatment., Competing Interests: The authors declare that they have no competing interests., (This journal is © The Royal Society of Chemistry.)