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Introduction: In spite of the restrictions associated with the sale of medicinal products over the past 8 years, the over-the-counter drug sales have nearly doubled. This is caused by a broad access to pharmaceuticals, abandonment of professional medical advice, and too many long queues to the general practitioner. Aim of the study: The aim of the study was to investigate the dependence in the use of over-the-counter analgesics among three age groups: students (generation I), their parents (generation II) and grandparents (generation III). Material and Methods: The research group consisted of 203 persons (150 women and 53 men) between 19 and 92 years of age (mean age: 48 years, SD: 22.18). The study used a diagnostic questionnaire based on the author’s questionnaire which asked the respondents about their health status and preferences in taking medicines. Results: The most commonly prescribed active ingredient for pain relievers in OTC drugs is ibuprofen (116 people - 65.91%). Then comes paracetamolum, which is chosen by 95 persons (53.98%). Acidum acetylsalicylicum attracts 58 people (32.95%). Less common are such substances as metamizol sodium, diclofenac and naproxenum. About 176 out of 203 respondents (86.70%) declare taking OTC painkillers “on their own”, 61 of them (85.92%) in generation I, 64 (90.14%) in generation II and 51 (83.61%) in generation III. Conclusions: The frequency of taking OTC painkillers in the members of particular generations of the family depends on their age. Older persons (15%) more often take analgesics several times a day. Only (1.4%) of the young do it. On the other hand, a considerably higher percentage of young people (75.7%) use such medications sporadically.