1. ASPECTE CALITATIVE ÎN DIAGNOSTICUL CITOGENETIC PRENATAL.
- Author
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Popescu, Gabriela and Stana, Adriana
- Subjects
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CYTOGENETICS , *CELL culture , *PRENATAL diagnosis , *AMNIOTIC liquid , *GESTATIONAL age , *METAPHASE (Mitosis) - Abstract
Objectives: Optimization of the quality of cell culture obtained by cultivating amniotic fluid cells and the quality of metaphases preparations and identification of the most important factors that should interfere with prenatal diagnosis of fetal chromosomal abnormalities. Material and methods: The effect on the outcome of our standard amniotic fluid cell long-term culture procedure of volume and appearance of the 561 submitted AF specimens, week of gestation and maternal age in which the specimen was taken and culture medium was systematically investigated. Results: Bloody or grossly bloody AF increases culture time and decreases number of clones/slide . On the other side, the maternal and the gestational age at amniocentesis had a great influence on metaphase quality. Conclusions: Variation in appearanc e of the amniotic fluid, maternal and the gestational age have significant effects on quality of cytogenetic analysis. [ABSTRACT FROM AUTHOR]
- Published
- 2012