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Introduction: The purpose of this research was to evaluate the serum level of vitamin C in patients with type 2 diabetes mellitus with and without periodontitis, and also to interpret whether raised or lessened serum vitamin C levels might be associated to a possibility for building oxidative stress in type 2 diabetes mellitus with periodontitis. Material and Methods: Investigation was conducted on diabetic subjects with and without periodontitis. The serum vitamin C level was determined using the 2, 4-dinitrophenylhydrazine method, and the spectrometer was used to read the concentration of serum vitamin C. The data attained were statistically calculated using the ANOVA test and post-hoc test. Results: The findings revealed that average serum vitamin C levels were reduced considerably among test groups (groups B, C, D) (p< 0.0001) in contrary to the healthy control group. Conclusion: The existing results are proof that reduced concentration of antioxidants such as vitamin C is related to a greater threat to the increase of oxidative stress in patients with type 2 diabetes mellitus and periodontitis. [ABSTRACT FROM AUTHOR]