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Breast cancer is the most common form of malignant tumour in females, its frequency being constantly increasing and being the second cause of mortality, after lung cancer, in women. The objective of the study is to evaluate the efficacy, performance and safety of modified radical mastectomy in clinical and technical terms in patients with breast cancer. Method and Results: A 5 year retrospective study was performed on the patients who underwent surgery for breast cancer. Of the 129 patients aged between 20 and 99 years, the maximum incidence is observed in the age group 60-69 years. The most used surgical procedures were: modified radical mastectomy (MRM) in 48 cases and sectorectomy in 32 cases. Madden type of MRM was performed in 95.83%, with no major intra or postoperative complications. Conclusions: Modified radical mastectomy is the first-choice surgery for patients diagnosed with breast cancer in more advanced stages of this disease, compared to conservative therapy which is indicated in the early stages of the disease. Active prophylaxis of surgical site infections was extremely important to achieve good cosmetic results of the surgical wound.