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Riverbed clogging is key to assessing vertical connectivity in the hyporheic zone and is often quantified using single‐parameter or qualitative approaches. However, clogging is driven by multiple, interacting physical and bio‐geochemical parameters, which do not allow for a conclusive assessment of hyporheic connectivity with single‐parameter approaches. In addition, existing qualitative assessments lack transparency and repeatability. This study introduces a Multi‐Parameter Approach to quantify Clogging and vertical hyporheic connectivity (MultiPAC), which builds on standardized measurements of physical (grain size characteristics, porosity, hydraulic conductivity) and bio‐geochemical (interstitial dissolved oxygen) parameters. We apply MultiPAC at three gravel‐bed rivers and show how the set of parameters provides a representative appreciation of physical riverbed clogging, thus quantifying vertical hyporheic connectivity. However, more parameters are required to fully characterize biological clogging. In addition, MultiPAC locates clogged layers in the hyporheic zone through multi‐parameter vertical profiles over the riverbed depth. The discussion outlines the relevance of MultiPAC to guide field surveys. [ABSTRACT FROM AUTHOR]