1. Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients
- Author
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Roelsgaard, Ida K, Ikdahl, Eirik, Rollefstad, Silvia, Wibetoe, Grunde, Esbensen, Bente A, Kitas, George D, van Riel, Piet, Gabriel, Sherine, Kvien, Tore K, Douglas, Karen, Wållberg-Jonsson, Solveig, Dahlqvist, Solbritt Rantapää, Karpouzas, George, Dessein, Patrick H, Tsang, Linda, El-Gabalawy, Hani, Hitchon, Carol A, Pascual-Ramos, Virginia, Contreras-Yáñez, Irazú, Sfikakis, Petros P, González-Gay, Miguel A, Crowson, Cynthia S, and Semb, Anne Grete
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Tobacco Smoke and Health ,Arthritis ,Prevention ,Cardiovascular ,Heart Disease ,Tobacco ,Clinical Research ,Good Health and Well Being ,Adult ,Aged ,Arthritis ,Rheumatoid ,Blood Pressure ,Cardiovascular Diseases ,Female ,Humans ,Lipoproteins ,Male ,Middle Aged ,Risk Factors ,Risk Reduction Behavior ,Severity of Illness Index ,Smoking ,Smoking Cessation ,rheumatoid arthritis ,epidemiology ,behaviour ,quality of life ,outcome measures ,Immunology ,Public Health and Health Services ,Arthritis & Rheumatology ,Clinical sciences - Abstract
ObjectivesSmoking is a major risk factor for the development of both cardiovascular disease (CVD) and RA and may cause attenuated responses to anti-rheumatic treatments. Our aim was to compare disease activity, CVD risk factors and CVD event rates across smoking status in RA patients.MethodsDisease characteristics, CVD risk factors and relevant medications were recorded in RA patients without prior CVD from 10 countries (Norway, UK, Netherlands, USA, Sweden, Greece, South Africa, Spain, Canada and Mexico). Information on CVD events was collected. Adjusted analysis of variance, logistic regression and Cox models were applied to compare RA disease activity (DAS28), CVD risk factors and event rates across categories of smoking status.ResultsOf the 3311 RA patients (1012 former, 887 current and 1412 never smokers), 235 experienced CVD events during a median follow-up of 3.5 years (interquartile range 2.5-6.1). At enrolment, current smokers were more likely to have moderate or high disease activity compared with former and never smokers (P
- Published
- 2020