1. Whole-body MRI in the diagnosis of paediatric CNO/CRMO
- Author
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Manigandan Thyagarajan, Hassan Douis, Jeremy Jones, Amaka C. Offiah, Savvas Andronikou, Andrea Zouvani, Jeannette K. Kraft, Athimalaipet V Ramanan, and Christian A. Barrera
- Subjects
medicine.medical_specialty ,Adolescent ,whole-body magnetic resonance imaging ,Whole body mri ,chronic recurrent multifocal osteomyelitis ,030218 nuclear medicine & medical imaging ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,children ,Rheumatology ,Bone Marrow ,Recurrence ,medicine ,Medical imaging ,Deformity ,Humans ,Whole Body Imaging ,Pharmacology (medical) ,Child ,030203 arthritis & rheumatology ,Bone Density Conservation Agents ,Diphosphonates ,Tibia ,Foot ,business.industry ,Osteomyelitis ,Chronic recurrent multifocal osteomyelitis ,osteomyelitis ,Hand ,medicine.disease ,Magnetic Resonance Imaging ,Spine ,Sagittal plane ,medicine.anatomical_structure ,Normal bone ,autoinflammatory ,Radiology ,medicine.symptom ,business - Abstract
Chronic recurrent multifocal osteomyelitis (CRMO) is an auto-inflammatory disorder affecting the skeleton of children and adolescents. Whole-body MRI (WBMRI) is key in the diagnosis and follow-up of CRMO. Imaging protocols should include sagittal short Tau inversion recovery of the spine, imaging of the hands and feet, and T1 images for distinguishing normal bone marrow. CRMO lesions can be metaphyseal, epiphyseal and physeal—potentially causing growth disturbance and deformity. Spinal lesions are common, important and can cause vertebral collapse. Lesion patterns include multifocal tibial and pauci-focal patterns that follow a predictable presentation and course of disease. Common pitfalls of WBMRI include haematopoietic marrow signal, metaphyseal signal early on in bisphosphonate therapy and normal high T2 signal in the hands and feet. Pictorial reporting assists in recording lesions and follow-up over time. The purpose of this paper is to review the different WBMRI protocols, imaging findings, lesion patterns and common pitfalls in children with CRMO
- Published
- 2020
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