1. Subclinical atherosclerosis in systemic lupus erythematosus (SLE): the relative contribution of classic risk factors and the lupus phenotype
- Author
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Yasmeen Ahmad, M. G. Walker, Joanna Shelmerdine, Mark Lunt, L-S Teh, M. G. Pattrick, Robert M. Bernstein, H. Bodill, and Ian N. Bruce
- Subjects
Adult ,medicine.medical_specialty ,Systemic disease ,Severity of Illness Index ,Gastroenterology ,Rheumatology ,immune system diseases ,Internal medicine ,medicine.artery ,Severity of illness ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Carotid Stenosis ,Pharmacology (medical) ,Risk factor ,skin and connective tissue diseases ,Ultrasonography ,Lupus erythematosus ,Systemic lupus erythematosus ,business.industry ,Smoking ,Age Factors ,Autoantibody ,Middle Aged ,Atherosclerosis ,medicine.disease ,Connective tissue disease ,Immunology ,Female ,Internal carotid artery ,Epidemiologic Methods ,business ,Carotid Artery, Internal - Abstract
Objectives. We aimed to examine the strength of association between traditional cardiovascular risk factors and carotid plaque development in systemic lupus erythematosus (SLE) patients and controls. We also aimed to determine which lupus-related factors are associated with carotid plaque and whether SLE sensitizes patients to the effects of traditional factors. Methods. We studied 200 women with SLE and 100 controls. Demographic and risk factor data were collected and SLE features, including autoantibody profiles and therapy were noted. All subjects had B- mode ultrasound of their carotid arteries examined for the presence and distribution of plaque. Results. SLE patients
- Published
- 2007
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