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Your search keyword '"SERIAL publications"' showing total 2 results
2 results on '"SERIAL publications"'

1. facts and fictions of precision medicine in autoimmune diseases: is the machine learning approach the response?

Author

Bartoloni, Elena, Perricone, Carlo, Cafaro, Giacomo, Alunno, Alessia, and Gerli, Roberto

Subjects
*BIOMARKERS, *SEQUENCE analysis, *SERIAL publications, *INDIVIDUALIZED medicine, *AUTOIMMUNE diseases, *MACHINE learning, *RNA, *SOFTWARE analytics, *DECISION making in clinical medicine
Abstract

The author discusses the facts and fictions of precision medicine in autoimmune diseases. Topics include why autoimmune diseases provide an excellent field for precision medicine model application, the application of cellular, molecular and transcriptional profiling and single-cell RNA sequencing of synovial tissue in the identification of rheumatoid arthritis patient clusters and the value of the integration of large molecular and clinical data from patients with autoimmune diseases.

Published
2022
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2. precision medicine trial in psoriatic arthritis—first jump in the deep end.

Author

Leijten, Emmerik F A

Subjects
*THERAPEUTIC use of monoclonal antibodies, *ANTIRHEUMATIC agents, *BIOMARKERS, *FLOW cytometry, *SERIAL publications, *PSORIATIC arthritis, *T cells, *PHENOTYPES, *TUMOR necrosis factors, *TREATMENT effectiveness, *INDIVIDUALIZED medicine, *CHEMICAL inhibitors, *GENETICS, *DIAGNOSIS, *THERAPEUTICS
Abstract

The article discusses a study on the immunologic heterogeneity within the overall group of patients classified as having psoriatic arthritis. The authors examined the efficacy of steering the choice of biologic on a per-patient immunologic basis in the strategic arm as compared with a standard-of-care approach. The authors have addressed recent calls for novel trial design. Slight caution is warranted as the strategic arm and standard-of-care arm were different in some key factors.

Published
2019
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