1. [Allergic diseases in children and farming environment]
- Author
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Hulin, M., Annesi-Maesano, Isabella, Epidémiologie des maladies infectieuses et modélisation (ESIM), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Male ,MESH: Immune Tolerance ,Adolescent ,MESH: Hypersensitivity ,MESH: Air Pollutants ,MESH: Environmental Exposure ,MESH: Disease Susceptibility ,Rural Health ,MESH: Models, Immunological ,MESH: Prenatal Exposure Delayed Effects ,MESH: Pregnancy ,Pregnancy ,MESH: Child ,Hypersensitivity ,Immune Tolerance ,Prevalence ,Respiratory Hypersensitivity ,Animals ,Humans ,MESH: Animals ,MESH: Animals, Domestic ,Genetic Predisposition to Disease ,Child ,MESH: Prevalence ,MESH: Adolescent ,Air Pollutants ,MESH: Humans ,MESH: Child, Preschool ,MESH: Genetic Predisposition to Disease ,Models, Immunological ,Agriculture ,Environmental Exposure ,MESH: Rural Health ,MESH: Male ,MESH: Milk ,MESH: Virus Diseases ,MESH: Respiratory Hypersensitivity ,Milk ,Virus Diseases ,Air Pollution, Indoor ,Animals, Domestic ,Child, Preschool ,Prenatal Exposure Delayed Effects ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,Disease Susceptibility ,MESH: Air Pollution, Indoor ,MESH: Female ,MESH: Agriculture - Abstract
International audience; INTRODUCTION: Children living in rural areas had lower prevalence of allergies than children from cities, in relation to farming exposure. STATE OF ART: Exposure to farm animals and consumption of raw milk appear to play an important role in the protection afforded by the agricultural environment, and this at different stages of child development. The mechanisms involved in these effects are still controversial, and recent publications cast doubt on the role of endotoxins initially suggested. It seems that exposure to indoor air pollution, characterized by excessive biocontaminants (mold, allergens...) is a key element in the development of allergic diseases. PERSPECTIVES: The establishment of cohort studies, a better assessment of exposure to pollution at home but also in farm buildings and the study of gene-environment interactions should improve the knowledge on the protective effect towards allergy of farming environment. CONCLUSIONS: The farming environment, very specific, could be an important model for better understanding the mechanisms involved in allergic and respiratory diseases. In addition, urbanization and thus reduction of the rural environment, may well explain the increased prevalence of allergies observed in the past 50 years.
- Published
- 2010
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