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Your search keyword '"M. Lecocq"' showing total 6 results
Start Over Author "M. Lecocq" Journal revue des maladies respiratoires
6 results on '"M. Lecocq"'

6. [Potential therapeutic implication of focal adhesion kinase in small-cell lung cancer].

Author

Decouvreur C, Lecocq M, Pilette C, Aboubakar Nana F, and Ocak S

Subjects
Animals, Mice, Humans, Focal Adhesion Protein-Tyrosine Kinases metabolism, Cell Movement, Small Cell Lung Carcinoma therapy, Lung Neoplasms therapy
Abstract

The molecular steps leading to small cell lung cancer (SCLC) development and progression are still poorly understood, resulting in the absence of targeted therapy and an extremely poor prognosis. Activation of Focal Adhesion Kinase (FAK) plays a key role in the invasive behavior of this cancer in vitro. Our hypothesis is that FAK could be a therapeutic target in SCLC. Our work aims to describe a mouse model to study the role of FAK and the antitumoral potential of its inhibition in SCLC in vivo., (Copyright © 2023 SPLF. Published by Elsevier Masson SAS. All rights reserved.)

Published
2023
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