1. Cortical metabolic changes and clinical outcome in normal pressure hydrocephalus after ventriculoperitoneal shunt: our preliminary results
- Author
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Chiaravalloti, A., Filippi, L., Bagni, O., Schillaci, O., Czosnyka, Z., Czosnyka, M., de Pandis, M. F., Federici, G., Galli, M., Pompucci, A., and Petrella, G.
- Subjects
Cerebral Cortex ,Male ,Positron emission tomography ,Fluorine Radioisotopes ,FDG ,General Engineering ,Ventriculoperitoneal Shunt ,Hydrocephalus, Normal Pressure ,Cognitive impairment ,Treatment Outcome ,Idiopathic normal pressure hydrocephalus ,Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,Humans ,General Earth and Planetary Sciences ,Gait analysis ,Female ,Postoperative Period ,Radiopharmaceuticals ,Cognition Disorders ,Gait Disorders, Neurologic ,Aged ,Retrospective Studies ,General Environmental Science - Abstract
Our objective was to evaluate the cortical metabolic changes and clinical outcome in patients affected by idiopathic normal pressure hydrocephalus (iNPH) after a placement of ventriculoperitoneal (VP) shunt.10 patients affected by suspected iNPH underwent a CSF hydrodynamics evaluation based on a lumbar infusion test (LIT). The main selection criterion for surgery was based on intracranial elasticity (IE)0.30. All subjects with an IE0.30 underwent a PET scan with 18 fluorodeoxiglucose (An overall number of 20 18F-FDG PET scans were performed in all the enrolled patients. As compared to PET1, PET2 showed an increase in glucose consumption in the left frontal and left parietal lobe in PET2 as compared to PET1 (P.001). All the enrolled patients presented a significant increase in neuropsychological scores (i.e Frontal Assessment Battery and Montreal Cognitive Assessment) and have clinically improved at gait analysis. A significant correlation was found between the increase of cortical glucose consumption in the left parietal area and the cognitive improvement as detectable by neuropsychological assessment.Improvement in 18F FDG PET glucose metabolism could be considered a useful imaging marker for the assessment of iNPH response to VP shunting.
- Published
- 2020
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