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Introduction: Giant-cell fibroma is a rare benign fibrous neoplasm of uncertain etiological factors and peculiar clinical-pathological characteristics. Objective: To describe the excision of giant-cell fibroma in the right jugal mucosa using surgical laser. Case report: A 33-year-old female patient, treated at the dental clinic of State University of Paraíba, due to neoplastic lesion, with slow growth in the region of the right jugal mucosa. Clinically, a single, asymptomatic tumor mass of approximately two centimeters, sessile, normocorated, with a firm consistency and a smooth surface was observed. After clinical examination, an excisional biopsy was performed for diagnostic purposes, using the surgical laser. The diagnosis, after the histopathological examination, revealed a giant-cell fibroma. The management of the excisional biopsy, in addition to having the purpose of oral diagnosis, was responsible for the treatment of the lesion, since it provided its complete removal. Second healing intention was chosen and, in order to accelerate this process, a local application with low-power red-light spectrum laser was carried out. At 7-day follow-up, adequate healing was observed, with minimal tissue change. After eight months, adequate tissue regeneration was observed without relapsed lesion. Conclusions: Removal of a giant-cell fibroma using high-power diode laser was shown to be a viable therapeutic approach for the treatment of this pathology.