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Start Over Author "Alla S Lisyanskaya" Journal reviews on clinical pharmacology and drug therapy
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1. Aromatase inhibitors of the third generation in endocrine therapy of breast cancer and endometrial cancer: the successes and failures of the combination therapy

Author

Ruslan Glushakov, Georgiy M Manikhas, Alla S Lisyanskaya, Ekaterina P Fadeeva, and Natalia I Tapilskaya

Subjects
Oncology, medicine.medical_specialty, 030219 obstetrics & reproductive medicine, Endometrial stromal sarcoma, Aromatase inhibitor, Combination therapy, biology, business.industry, medicine.drug_class, Endometrial cancer, General Medicine, medicine.disease, Antiestrogen, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, 030220 oncology & carcinogenesis, Internal medicine, medicine, biology.protein, Aromatase, business, Tamoxifen, medicine.drug
Abstract

This review provides the current evidence of clinical studies on the effectiveness of endocrine therapy for breast cancer and endometrial cancer, including endometrial stromal sarcoma, by aromatase inhibitor (AI) III generation. The review presents dates from clinical trials comparing the effectiveness of AI and tamoxifen, as well as dates on combination therapy AI with inhibitors of mTOR pathway (BOLERO-2 trial), an antiestrogen (SWOG S0226, FACT, FIRST trials), an inhibitor of CDK4 / 6 (PALOMA -1 trial) and other drugs.

Published
2016
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