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The article examines the metrics used for measuring qualitative data and the scales utilized for grading signs of ocular disease. Topics discussed include the statistical tests for measuring agreement, the high concordance that can result from using scale, and the preference for measurement scales that can identify clinical change in patients. The scales utilized for assess staining and rating redness and management of complex clinical presentations are mentioned.

The article focuses on clinical models of a disease which offer useful information about an ailment and treatment of the disease. It highlights several conditions of diseases that can be best served by the clinical models including strong subjective component, inherent temporal variability and significant placebo efficacy. It discusses the conjunctival allergen challenge (CAC) and the controlled adverse environment (CAE) models of the ocular allergy and dry eye diseases.

The article focuses on the process known as allergen priming which plays a significant role in eye disease allergic conjunctivitis. The article discusses several topics related to disease and its treatment which includes allergens and Priming, priming and Tolerance and initial response to allergens. It also mentions several cells of immune system that involve in the process of allergic response.

The article focuses on the aspects of vasoconstrictors such as its mechanisms and possible side effects. It cites several ocular vasoconstrictors that are used as adrenergic receptor antagonists including naphalozine, phenylephrine and oxymetazoline. It states that the said agents are associated with different adverse effects such as tachyphylaxis, tolerance and vasodilation.

The article presents information on the dry eye disease, the changes induced by which in the visual function are more subtle and transient compared to permanent vision loss. It informs that the disease can lead to tear-film breakup, increased blink rate and corneal desiccation. It further informs that the drying cornea sends out signals stimulating blinking, in a defensive effort to refresh tears.