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Your search keyword '"Michelle Connole"' showing total 2 results
Start Over Author "Michelle Connole" Journal retrovirology
2 results on '"Michelle Connole"'

1. SIVΔnef vaccination mobilizes systemic and mucosal natural killer cells in Mamu A*01+ macaques

Author

Michelle Connole, Roger Keith Reeves, Fay E. Wong, Yi Yu, R P Johnson, Jacqueline Gillis, and Tristan I. Evans

Subjects
Vaccination, lcsh:Immunologic diseases. Allergy, Innate immune system, Immune system, Infectious Diseases, animal diseases, Virology, biology.protein, Oral Presentation, Biology, Antibody, lcsh:RC581-607
Abstract

Background Although vaccination with live attenuated SIV is the most effective means of inducing protection against lentiviruses, the immunologic mechanisms responsible remain unclear. Previous studies have yielded conflicting data regarding the role of adaptive immune responses in mediating protection, suggesting that innate immune responses, including natural killer (NK) cells, may play a role.

Published
2012

2. Maturation of protective immunity induced by SIVΔnef correlates with differential expression of transcription factors in SIV-specific CD8+ T cells

Author

James M. Billingsley, Wenjun Li, Nadine C. Salisch, Henoch S. Hong, R P Johnson, Premeela A. Rajakumar, Yury V. Kuzmichev, Roger Keith Reeves, Michelle Connole, and H Kang

Subjects
lcsh:Immunologic diseases. Allergy, biology, business.industry, animal diseases, T cell, virus diseases, chemical and pharmacologic phenomena, C-C chemokine receptor type 7, Bioinformatics, medicine.anatomical_structure, Infectious Diseases, Downregulation and upregulation, Virology, Immunology, Poster Presentation, biology.protein, Medicine, Cytotoxic T cell, Antibody, business, Interleukin-7 receptor, lcsh:RC581-607, Transcription factor, CD8
Abstract

Background Protective immunity against vaginal challenge in SIVΔnef-vaccinated macaques develops at 20 weeks after vaccination, whereas the magnitude of SIV-specific CD8+ T cell responses peaks at 5 weeks. SIV-specific CD8+ T cells phenotypically mature from week 5 to 20, as characterized by upregulation of CCR7 and CD127, suggesting that the quality of the CD8+ T cell response may correlate with protection.

Published
2012

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