1. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF SUBRETINAL FIBROSIS AFTER MYOPIC NEOVASCULARIZATION
- Author
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Amedeo Massacesi, Roberta Secondi, M. Setaccioli, Stefania Moschini, Fabrizio Scotti, Marco Antonio Pellegrini, Fulvio Bergamini, and Paolo Milani
- Subjects
Adult ,Male ,medicine.medical_specialty ,genetic structures ,Fundus Oculi ,Refraction, Ocular ,01 natural sciences ,010309 optics ,Neovascularization ,03 medical and health sciences ,0302 clinical medicine ,Retinal Diseases ,Optical coherence tomography ,Ophthalmology ,0103 physical sciences ,Myopia ,medicine ,Humans ,Fluorescein Angiography ,Aged ,Retrospective Studies ,Aged, 80 and over ,Retina ,medicine.diagnostic_test ,Choroid ,business.industry ,General Medicine ,Blood flow ,Optical coherence tomography angiography ,Middle Aged ,Fluorescein angiography ,Fibrosis ,Choroidal Neovascularization ,eye diseases ,Cross-Sectional Studies ,medicine.anatomical_structure ,Angiography ,030221 ophthalmology & optometry ,Female ,sense organs ,Subretinal fibrosis ,medicine.symptom ,business ,Tomography, Optical Coherence - Abstract
Purpose To describe the optical coherence tomography (OCT) angiography features of subretinal fibrosis in eyes with myopic choroidal neovascularization after natural evolution or secondary to intravitreal anti-vascular endothelial growth factor therapy. Methods Retrospective observational case series. All eyes underwent a multimodal imaging examination including fluorescein angiography, spectral domain OCT, OCT angiography, and en face OCT. Results Twenty-five eyes of 25 patients with mean age of 56.4 ± 14.9 were included in the study. Subretinal fibrosis was diagnosed at mean 30 (range 6-116) months before inclusion. Within the subretinal fibrosis, an abnormal vascular network was observed in 20/25 (80%) eyes, located typically in the outer retina (18/20, 90%) or the choriocapillaris (14/20, 70%) segmentation. The most prevalent patterns were "round tangle" and "tapered tangle." On en face OCT, the subretinal fibrosis was evidenced in 24/25 (96%) eyes, most prevalently in the outer retina (21/25, 84%) and in the choriocapillaris (18/25, 72%), where main feature was white-hyperreflective (20/21, 95%) and dark-hyporeflective (17/18, 94%) appearance, respectively. The presence of subretinal fibrosis on en face OCT was positively correlated with the presence of abnormal vascular network on OCT angiography in 61% of the cases (P = 0.005). Conclusion Subretinal fibrosis secondary to myopic choroidal neovascularization frequently contains blood flow within a persistent abnormal vascular network as assessed by OCT angiography.
- Published
- 2020
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