1. Polymorphisms of interferon-γ and interferon-γ receptor 1 genes and pulmonary tuberculosis in Koreans
- Author
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Miyeon Kang, Gee Young Suh, Shin‐Hye Lee, Yongick Ji, O Jung Kwon, Su Yeon Kim, Eunjoo Kim, Won-Jung Koh, Jung Hye Hwang, and Duk-Hwan Kim
- Subjects
Male ,Pulmonary and Respiratory Medicine ,Mutation ,Korea ,business.industry ,Point mutation ,medicine.disease_cause ,Interferon-gamma ,Asian People ,Interferon-gamma receptor ,Genotype ,Immunology ,Genetic variation ,medicine ,Humans ,Female ,Interferon gamma ,business ,Tuberculosis, Pulmonary ,Allele frequency ,Gene ,Receptors, Interferon ,medicine.drug - Abstract
Background and objective: Many genetic variations are thought to be risk factors for the development of pulmonary tuberculosis (TB). The association of interferon-γ (IFN-γ) and IFN-γ receptor 1 (IFN-γR1) gene polymorphisms with pulmonary TB is controversial. This study examined the association between IFN-γ and IFN-γR1 gene polymorphisms and pulmonary TB among Koreans. Methods: Eighty patients with culture-confirmed pulmonary TB and 80 controls were studied. Polymorphisms of the IFN-γ gene at position +874 were determined using the amplification refractory mutation system PCR assay, and the IFN-γR1 gene was genotyped at positions −611, −270, −56 and +95 employing matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using genomic DNA. Results: The genotype and allele frequencies of the IFN-γ and IFN-γR1 gene polymorphisms did not differ significantly between the patients with pulmonary TB and controls. Conclusions: The IFN-γ and IFN-γR1 gene polymorphisms do not appear to be responsible for host susceptibility to pulmonary TB in the Korean population.
- Published
- 2007
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