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Your search keyword '"Nakanishi, Yoichi"' showing total 26 results
Start Over Author "Nakanishi, Yoichi" Journal respirology
26 results on '"Nakanishi, Yoichi"'

6. The Role of Bax in Lung Fibrosis: PS415

Author

Suzuki, Kunihiro, Maeyama, Takashige, Yokoyama, Tetsuya, Ogata, Saiko, Kudoh, Kunihiro, Mikumo, Hironori, Mizuta, Yuocji, Hamada, Naoki, Inoshima, Ichiro, Kuwano, Kazuyoshi, and Nakanishi, Yoichi

Published
2013

23. A case of extrapleural empyema

Author

OSAKI, SHIN-ICHI, NAKANISHI, YOICHI, ANDOU, KOUEI, TAKANO, KOICHI, TAKAYAMA, KOICHI, HIROTA, NOBUO, ISHIBASHI, TSUNEO, and HARA, NOBUYUKI

Published
2002

26. Frequency of Foxp3+CD4+CD25+ T cells is associated with the phenotypes of allergic asthma.

Author

MATSUMOTO, Koichiro, INOUE, Hiromasa, FUKUYAMA, Satoru, KAN-O, Keiko, EGUCHI-TSUDA, Miyuki, MATSUMOTO, Takafumi, MORIWAKI, Atsushi, NAKANO, Takako, and NAKANISHI, Yoichi

Subjects
T cells, PHENOTYPES, ASTHMA, ASTHMATICS, INFLAMMATION, CD antigens
Abstract

Background and objective: A forkhead/winged-helix family transcriptional repressor, Foxp3, is highly expressed on CD4+CD25+ T regulatory cells. The role of Foxp3+CD4+CD25+ T regulatory cells in asthma remains to be elucidated. Using mouse models and peripheral blood mononuclear cells (PBMC) from subjects with allergic asthma, we aimed to explore whether Foxp3+CD4+CD25+ T regulatory cells associate with asthma phenotypes. Methods: Foxp3+CD4+CD25+ T cells were detected by FACS and the correlation between the frequency of Foxp3+CD4+CD25+ T cells and asthma phenotypes was assessed. Results: The frequency of Foxp3+CD4+CD25+ T cells among total CD4+CD25+ T cells in the lungs showed an inverse correlation with eosinophilic inflammation in BALB/c, A/J and C57BL/6 strains. In addition, the frequency of Foxp3+CD4+CD25+ T cells was inversely correlated with BHR and allergen-specific IgE levels in the serum of A/J mice. In BALB/c mice, the frequency of Foxp3+CD4+CD25+ T cells correlated with the level of IL-10 in BAL fluid. The inverse correlation between the frequency of Foxp3+CD4+CD25+ T cells and eosinophilic inflammation disappeared when mice were treated with anti-IL-10 receptor mAb during allergen challenge. Interestingly, intracellular cytokine staining of lung cells revealed that IL-10 was predominantly produced by Foxp3-CD4+CD25+ T cells. The frequency of Foxp3+CD4+CD25+ T cells among total CD4+CD25+ T cells in PBMC of asthmatics was significantly lower than that of healthy subjects, although there was no significant correlation between the frequency of Foxp3+CD4+CD25+ T cells and asthma severity. Conclusions: These results suggest a role for lung Foxp3+CD4+CD25+ T cells in the regulation of asthma phenotypes, presumably through an IL-10-mediated mechanism. [ABSTRACT FROM AUTHOR]

Published
2009
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