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Start Over Descriptor "RDW" Journal respiratory research
4 results on '"RDW"'

1. Increased monocyte count and red cell distribution width as prognostic biomarkers in patients with Idiopathic Pulmonary Fibrosis

Author

Theodoros Karampitsakos, Sebastiano Torrisi, Katerina Antoniou, Effrosyni Manali, Ioanna Korbila, Ourania Papaioannou, Fotios Sampsonas, Matthaios Katsaras, Eirini Vasarmidi, Despoina Papakosta, Kalliopi Domvri, Eva Fouka, Ioannis Organtzis, Zoe Daniil, Ilias Dimeas, Paraskevi Kirgou, Konstantinos I. Gourgoulianis, Ilias C. Papanikolaou, Katerina Markopoulou, Georgia Kounti, Eirini Tsapakidou, Efthymia Papadopoulou, Konstantinos Tatsis, Athena Gogali, Konstantinos Kostikas, Vasilios Tzilas, Serafeim Chrysikos, Spyridon Papiris, Demosthenes Bouros, Michael Kreuter, and Argyrios Tzouvelekis

Subjects
Monocyte count, RDW, Idiopathic pulmonary fibrosis, Biomarkers, Mortality, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Idiopathic Pulmonary Fibrosis (IPF) represents a chronic lung disease with unpredictable course. Methods We aimed to investigate prognostic performance of complete blood count parameters in IPF. Treatment-naïve patients with IPF were retrospectively enrolled from two independent cohorts (derivation and validation) and split into subgroups (high and low) based on median baseline monocyte count and red cell distribution width (RDW). Results Overall, 489 patients (derivation cohort: 300, validation cohort: 189) were analyzed. In the derivation cohort, patients with monocyte count ≥ 0.60 K/μL had significantly lower median FVC%pred [75.0, (95% CI 71.3–76.7) vs. 80.9, (95% CI 77.5–83.1), (P = 0.01)] and DLCO%pred [47.5, (95% CI 44.3–52.3) vs. 53.0, (95% CI 48.0–56.7), (P = 0.02)] than patients with monocyte count

Published
2021
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2. Increased monocyte count and red cell distribution width as prognostic biomarkers in patients with Idiopathic Pulmonary Fibrosis.

Author

Karampitsakos, Theodoros, Torrisi, Sebastiano, Antoniou, Katerina, Manali, Effrosyni, Korbila, Ioanna, Papaioannou, Ourania, Sampsonas, Fotios, Katsaras, Matthaios, Vasarmidi, Eirini, Papakosta, Despoina, Domvri, Kalliopi, Fouka, Eva, Organtzis, Ioannis, Daniil, Zoe, Dimeas, Ilias, Kirgou, Paraskevi, Gourgoulianis, Konstantinos I., Papanikolaou, Ilias C., Markopoulou, Katerina, and Kounti, Georgia

Subjects
*IDIOPATHIC pulmonary fibrosis, *ERYTHROCYTES, *PROGNOSIS, *BLOOD cell count
Abstract

Background: Idiopathic Pulmonary Fibrosis (IPF) represents a chronic lung disease with unpredictable course.Methods: We aimed to investigate prognostic performance of complete blood count parameters in IPF. Treatment-naïve patients with IPF were retrospectively enrolled from two independent cohorts (derivation and validation) and split into subgroups (high and low) based on median baseline monocyte count and red cell distribution width (RDW).Results: Overall, 489 patients (derivation cohort: 300, validation cohort: 189) were analyzed. In the derivation cohort, patients with monocyte count ≥ 0.60 K/μL had significantly lower median FVC%pred [75.0, (95% CI 71.3-76.7) vs. 80.9, (95% CI 77.5-83.1), (P = 0.01)] and DLCO%pred [47.5, (95% CI 44.3-52.3) vs. 53.0, (95% CI 48.0-56.7), (P = 0.02)] than patients with monocyte count < 0.60 K/μL. Patients with RDW ≥ 14.1% had significantly lower median FVC%pred [75.5, (95% CI 71.2-79.2) vs. 78.3, (95% CI 76.0-81.0), (P = 0.04)] and DLCO%pred [45.4, (95% CI 43.3-50.5) vs. 53.0, (95% CI 50.8-56.8), (P = 0.008)] than patients with RDW < 14.1%. Cut-off thresholds from the derivation cohort were applied to the validation cohort with similar discriminatory value, as indicated by significant differences in median DLCO%pred between patients with high vs. low monocyte count [37.8, (95% CI 35.5-41.1) vs. 45.5, (95% CI 41.9-49.4), (P < 0.001)] and RDW [37.9, (95% CI 33.4-40.7) vs. 44.4, (95% CI 41.5-48.9), (P < 0.001)]. Patients with high monocyte count and RDW of the validation cohort exhibited a trend towards lower median FVC%pred (P = 0.09) and significantly lower median FVC%pred (P = 0.001), respectively. Kaplan-Meier analysis in the derivation cohort demonstrated higher all-cause mortality in patients with high (≥ 0.60 K/μL) vs. low monocyte count (< 0.60 K/μL) [HR 2.05, (95% CI 1.19-3.53), (P = 0.01)].Conclusions: Increased monocyte count and RDW may represent negative prognostic biomarkers in patients with IPF. [ABSTRACT FROM AUTHOR]

Published
2021
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3. Increased monocyte count and red cell distribution width as prognostic biomarkers in patients with Idiopathic Pulmonary Fibrosis

Author

Konstantinos I. Gourgoulianis, Effrosyni D. Manali, Ourania Papaioannou, Vasilios Tzilas, Paraskevi Kirgou, Katerina Markopoulou, Matthaios Katsaras, Sebastiano Emanuele Torrisi, Efthymia Papadopoulou, Zoe Daniil, Katerina M. Antoniou, Konstantinos Kostikas, Ilias Papanikolaou, Ilias Dimeas, Ioanna Korbila, Eva Fouka, Serafeim Chrysikos, Eirini Tsapakidou, Athena Gogali, Demosthenes Bouros, Theodoros Karampitsakos, Eirini Vasarmidi, Despoina Papakosta, Spyridon Papiris, Kalliopi Domvri, Ioannis Organtzis, Argyrios Tzouvelekis, Michael Kreuter, Fotios Sampsonas, Konstantinos Tatsis, and Georgia Kounti

Subjects
Erythrocyte Indices, Male, medicine.medical_specialty, Erythrocytes, Regression model, Vital Capacity, Idiopathic pulmonary fibrosis, Monocyte, Gastroenterology, Monocytes, Leukocyte Count, 03 medical and health sciences, Diseases of the respiratory system, 0302 clinical medicine, Monocyte count, High monocyte count, Predictive Value of Tests, Internal medicine, Humans, Medicine, RDW, In patient, 030212 general & internal medicine, Derivation, Mortality, Lung, Letter to the Editor, Aged, Retrospective Studies, Greece, medicine.diagnostic_test, RC705-779, business.industry, Reproducibility of Results, Complete blood count, Red blood cell distribution width, Prognosis, medicine.disease, medicine.anatomical_structure, 030228 respiratory system, Female, business, Biomarkers
Abstract

Background Idiopathic Pulmonary Fibrosis (IPF) represents a chronic lung disease with unpredictable course. Methods We aimed to investigate prognostic performance of complete blood count parameters in IPF. Treatment-naïve patients with IPF were retrospectively enrolled from two independent cohorts (derivation and validation) and split into subgroups (high and low) based on median baseline monocyte count and red cell distribution width (RDW). Results Overall, 489 patients (derivation cohort: 300, validation cohort: 189) were analyzed. In the derivation cohort, patients with monocyte count ≥ 0.60 K/μL had significantly lower median FVC%pred [75.0, (95% CI 71.3–76.7) vs. 80.9, (95% CI 77.5–83.1), (P = 0.01)] and DLCO%pred [47.5, (95% CI 44.3–52.3) vs. 53.0, (95% CI 48.0–56.7), (P = 0.02)] than patients with monocyte count P = 0.04)] and DLCO%pred [45.4, (95% CI 43.3–50.5) vs. 53.0, (95% CI 50.8–56.8), (P = 0.008)] than patients with RDW P P P = 0.09) and significantly lower median FVC%pred (P = 0.001), respectively. Kaplan–Meier analysis in the derivation cohort demonstrated higher all-cause mortality in patients with high (≥ 0.60 K/μL) vs. low monocyte count (P = 0.01)]. Conclusions Increased monocyte count and RDW may represent negative prognostic biomarkers in patients with IPF.

Published
2021

4. Monocyte as a prognostic marker in patients with idiopathic pulmonary fibrosis

Author

Shiping Zhu

Subjects
medicine.medical_specialty, RC705-779, business.industry, Research, Regression model, Monocyte, Idiopathic pulmonary fibrosis, Prognosis, medicine.disease, Gastroenterology, Monocytes, Diseases of the respiratory system, medicine.anatomical_structure, Internal medicine, Monocyte count, medicine, Humans, RDW, In patient, Mortality, Respiratory system, business, Biomarkers
Abstract

Background Idiopathic Pulmonary Fibrosis (IPF) represents a chronic lung disease with unpredictable course. Methods We aimed to investigate prognostic performance of complete blood count parameters in IPF. Treatment-naïve patients with IPF were retrospectively enrolled from two independent cohorts (derivation and validation) and split into subgroups (high and low) based on median baseline monocyte count and red cell distribution width (RDW). Results Overall, 489 patients (derivation cohort: 300, validation cohort: 189) were analyzed. In the derivation cohort, patients with monocyte count ≥ 0.60 K/μL had significantly lower median FVC%pred [75.0, (95% CI 71.3–76.7) vs. 80.9, (95% CI 77.5–83.1), (P = 0.01)] and DLCO%pred [47.5, (95% CI 44.3–52.3) vs. 53.0, (95% CI 48.0–56.7), (P = 0.02)] than patients with monocyte count

Published
2021

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