1. The role of pleiotrophin and beta-catenin in fetal lung development.
- Author
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Weng T, Liu L, Weng, Tingting, and Liu, Lin
- Subjects
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ANIMALS , *CARRIER proteins , *CELL differentiation , *CELL communication , *CELL physiology , *CELLULAR signal transduction , *CYTOKINES , *CYTOSKELETAL proteins , *EPITHELIAL cells , *FIBROBLASTS , *GLYCOPROTEINS , *LUNGS , *LUNG diseases , *MORPHOGENESIS , *RESEARCH funding - Abstract
Mammalian lung development is a complex biological process, which is temporally and spatially regulated by growth factors, hormones, and extracellular matrix proteins. Abnormal changes of these molecules often lead to impaired lung development, and thus pulmonary diseases. Epithelial-mesenchymal interactions are crucial for fetal lung development. This paper reviews two interconnected pathways, pleiotrophin and Wnt/beta-catenin, which are involved in fibroblast and epithelial cell communication during fetal lung development. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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