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Start Over Author "Milman N" Journal respiratory medicine
8 results on '"Milman N"'

5. Increased serum YKL-40 in patients with pulmonary sarcoidosis-a potential marker of disease activity?

Author

Johansen, J.S., Milman, N., Hansen, M., Garbarsch, C., Price, P.A., and Graudal, N.

Abstract

Background: YKL-40, a growth factor for fibroblasts and vascular endothelial cells, is secreted by macrophages and neutrophils. Elevated serum YKL-40 is found in patients with diseases characterized by inflammation, tissue remodelling and ongoing fibrosis. The aim was to evaluate whether macrophages and giant cells in the granulomatous sarcoid lesions of patients with pulmonary sarcoidosis produce YKL-40 and to determine whether serum YKL-40 in these patients were associated with disease activity. Methods: Serum YKL-40 was determined by radioimmunoassay in 27 patients with a histological diagnosis of pulmonal sarcoidosis. Immunohistochemical staining for YKL-40 antigen was performed in five biopsies with pulmonary sarcoid lesions. Serum YKL-40 was likewise measured in 173 healthy age-matched control subjects. Results: Mononuclear cells/macrophages and giant cells in pulmonary sarcoid granulomas expressed YKL-40 protein. Serum YKL-40 was higher in patients with pulmonary sarcoidosis compared to controls (P<0.001) and 63% had elevated serum YKL-40. There was a positive correlation between serum YKL-40 and serum angiotensin converting enzyme (rho=0.55, P=0.0053). Patients with serum YKL-40>median value in the patient group had lower carbon monoxide diffusion capacity corrected for alveolar volume (D"LCO/VA) than patients with serum YKL-40=

Published
2005
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7. Health-related quality of life in adult survivors of childhood sarcoidosis.

Author

Milman N, Svendsen CB, and Hoffmann AL

Subjects
Adolescent, Adult, Child, Child, Preschool, Denmark epidemiology, Epidemiologic Methods, Humans, Male, Prognosis, Radiography, Respiratory Function Tests, Sarcoidosis complications, Sarcoidosis diagnostic imaging, Young Adult, Health Status, Quality of Life, Sarcoidosis epidemiology, Survivors
Abstract

Aim: To describe health-related quality of life (hrQOL) in adult subjects who had sarcoidosis in childhood., Methods: Forty-six children (24 boys), all ethnic Danes

Published
2009
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8. Ficolins and Mannose-Binding Lectin in Danish patients with sarcoidosis.

Author

Svendsen CB, Hummelshøj T, Munthe-Fog L, Milman N, Garred P, Laursen IA, Christiansen M, and Krogfelt KA

Subjects
Adult, Analysis of Variance, Biomarkers blood, Case-Control Studies, Denmark, Enzyme-Linked Immunosorbent Assay methods, Female, Humans, Male, Middle Aged, Retrospective Studies, Statistics, Nonparametric, Ficolins, Glycoproteins blood, Lectins blood, Mannose-Binding Lectin blood, Sarcoidosis blood
Abstract

Mannose-Binding Lectin (MBL) is a prognostic marker in pulmonary diseases. Ficolins, sharing many structural and functional similarities with MBL, may also be involved in the pathogenesis of pulmonary diseases. The objectives of the study were to establish whether plasma concentrations of Ficolin-2, -3, and MBL in Danish patients with sarcoidosis and control persons differed and whether they were of prognostic significance. We retrospectively included 46 consecutive patients (26 male, 20 female) and 51 age- and sex-matched healthy control persons (28 male, 23 female). Information about the patients was obtained from their medical records. We measured plasma concentrations of Ficolin-2, -3, and MBL using ELISA. There was a significant difference in the patients' mean Ficolin-3 plasma level (14.9 microg/ml; +/-2SD: 6.7-23.1) compared with the control persons' (21.6 microg/ml; +/-2SD: 12.7-30.5). The difference was 6.7 microg/ml (95% CI: 5.0-8.4 microg/ml; p<0.001). In the patients, Ficolin-3 correlated inversely with the CD4(+)/CD8(+)-ratio (Spearman's Rho=-0.37; p=0.021; n=39). There were no significant differences in plasma concentrations of Ficolin-2 or MBL between the two groups. Ficolin-3 concentrations were lower in plasma from patients with sarcoidosis. This suggests a possible involvement of Ficolin-3 in the complex pathophysiology of sarcoidosis. However, we could not show the applicability of Ficolin plasma level measurement as a marker of disease activity or of prognostic significance in sarcoidosis.

Published
2008
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