1. Clinical significance of respiratory virus detection in patients with acute exacerbation of interstitial lung diseases
- Author
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Masachika Fujiwara, Mitsuru Sada, Manami Inoue, Kosuke Ohkuma, Daisuke Kurai, Takuma Yokoyama, Miku Oda, Hajime Takizawa, Yukari Ogawa, Kojiro Honda, Takeshi Saraya, Masaki Tamura, Hirokazu Kimura, Takayasu Watanabe, Haruyuki Ishii, Masato Watanabe, and Sunao Mikura
- Subjects
Male ,Short term mortality ,Non-IPF interstitial lung disease ,Exacerbation ,Kaplan-Meier Estimate ,Gastroenterology ,Idiopathic pulmonary fibrosis ,PCR, polymerase chain reaction ,0302 clinical medicine ,CTD, connective tissue disease ,Japan ,BALF, bronchoalveolar lavage fluid ,Prospective Studies ,030212 general & internal medicine ,UIP, usual interstitial pneumonia ,Connective Tissue Diseases ,HMPV, human metapneumovirus ,Virus detection ,Aged, 80 and over ,medicine.diagnostic_test ,Interstitial lung disease ,ILDs, interstitial lung diseases ,respiratory system ,IIP, idiopathic interstitial pneumonia ,humanities ,HPIV, human parainfluenza viruses ,Acute exacerbation ,Virus Diseases ,Acute Disease ,Respiratory virus ,Female ,medicine.symptom ,Bronchoalveolar Lavage Fluid ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,HRV, human rhinovirus ,Article ,03 medical and health sciences ,Internal medicine ,medicine ,IPF, idiopathic pulmonary fibrosis ,Humans ,HHV, human herpes virus ,Idiopathic Interstitial Pneumonias ,Idiopathic interstitial pneumonia ,Aged ,business.industry ,Sputum ,CMV, cytomegalovirus ,medicine.disease ,respiratory tract diseases ,HRSV, human respiratory syncytial virus ,Pneumonia ,IPF ,Bronchoalveolar lavage ,030228 respiratory system ,Lung Diseases, Interstitial ,business - Abstract
Background The impact of viral infections on acute exacerbations in idiopathic pulmonary fibrosis (IPF) and/or non-IPF interstitial lung disease (ILDs) has been scarcely described. Objectives To elucidate the frequency of virus infections in patients with IPF or non-IPF ILDs including idiopathic interstitial pneumonia (IIP) or connective tissue disease (CTD)-associated pneumonia, and its influence on their short-term mortality. Methods We prospectively enrolled adult patients with acute exacerbation of IPF and non-IPF ILDs who were admitted to the hospital during the last 3 years, and examined the respiratory samples obtained from nasopharyngeal, sputum, and bronchoalveolar lavage fluid. Results A total of 78 patients were identified, consisting of 27 patients with acute exacerbation of IPF and 51 patients with non-IPF ILDs (IIP: n = 27, CTD-associated IP: n = 24). Of all patients, 15 (19.2%) had viruses detected in their respiratory samples including the human herpesvirus 7 (HHV7; n = 4) and cytomegalovirus (CMV) plus HHV7 (n = 3). The proportion of virus infections in the IPF and non-IPF ILDs groups was comparable. The Kaplan-Meier survival curves over 60 days revealed a lower survival probability in the virus positive group (n = 15, 60%) than in the virus negative group (n = 60, 83.3%, p
- Published
- 2018
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