1. Point-of-care Arkansas method for measuring adherence to treatment with isoniazid
- Author
-
Renata Leborato Guerra, Gisele Bastos, Marcus Barreto Conde, Carla Loredo, Anne Efron, Richard E. Chaisson, and Jonathan E. Golub
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Tuberculosis ,Hospital setting ,Antitubercular Agents ,Medication adherence ,Sensitivity and Specificity ,Article ,Medication Adherence ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Isoniazid ,Humans ,Arkansas method ,heterocyclic compounds ,Latent tuberculosis infection ,030212 general & internal medicine ,Tuberculosis, Pulmonary ,Point of care ,business.industry ,Tobacco smoke exposure ,biochemical phenomena, metabolism, and nutrition ,respiratory system ,medicine.disease ,bacterial infections and mycoses ,3. Good health ,Surgery ,respiratory tract diseases ,Preventive therapy ,Adherence ,030220 oncology & carcinogenesis ,Chemoprophylaxis ,Female ,business ,Brazil ,medicine.drug - Abstract
Summary We evaluated the accuracy of a point-of-care test designed to measure adherence to isoniazid (INH) preventive therapy in a hospital setting in Rio de Janeiro, Brazil. Patients on treatment with daily INH and patients not receiving INH were included. Sensitivity and specificity of the test were 84%/98% at the first minute, and 95%/98% at the fifth minute, respectively. Among smokers, sensitivity and specificity was reduced (80%/89% at the fifth minute, respectively), but only 17% smoked. This test accurately detected INH metabolites 24 h following directly observed INH intake, though sensitivity and specificity may be compromised by tobacco smoke exposure.
- Published
- 2010
- Full Text
- View/download PDF