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1. Contents Vol. 80, 2010

Author

Mehmet Ali Kaplan, Ziemowit Zietkowski, Luigi Busiello, H.A.C. van Helvoort, Nazanin Zamanian Rohani, Z. Zietkowski, Ramon Farré, Mark J. Rumbak, Guang-Nan Liu, Stephanie P. Pezzo, Tae-Hoon Jung, Abdurrahman Abakay, Mirjam Christ-Crain, Shaul Lev, Abdullah Cetin Tanrikulu, Giovanni Vicidomini, Xiao-Ning Zhong, Christian Mueller, Argyris Tzouvelekis, Pier Francesco Rambaldi, Juan F. Masa, Milana Grinev, Andrea Azzola, Mohsen Davoudi, P.N.R. Dekhuijzen, Y.F. Heijdra, Luigi Mansi, Roman Skiepko, Joaquín Durán, R. Skiepko, Michael Roth, Alfonso Fiorelli, Yael A. Glickman, Georgia Trakada, Zhi-Yi He, Daniel Navajas, J.B. Peters, Paula Virkkula, Evangelia Nena, Irene Tsilioni, Kyung Min Shin, Osnat Moreh-Rahav, Micha T. Maeder, Brice Taylor, Ilya Kagan, David Dahan, Mario Santini, Arnoldo Guerrero, Udo Schirp, Anna Bodzenta-Lukaszyk, Cengizhan Sezgi, Thenral Socrates, Konstantinos I. Gourgoulianis, Christophe von Garnier, M.M. Tomasiak-Lozowska, Henri G. Colt, Hanna-Riikka Kreivi, Theodoros Kiropoulos, Jian-Quan Zhang, Osman Evliyaoglu, B. Mroczko, J.M. Montserrat, Pierre Singer, Olga Hatzizisi, Mei-Hua Li, Marios Froudarakis, M Shapiro, Irene Gerogianni, Richard G. Hegele, Smaragda Oikonomidi, Shin-Yup Lee, Paschalina Tsopa, Cristina Embid, Roberto Duranti, Juho T. Lehto, Miriam Reiter, Maria M. Tomasiak-Lozowska, Li-Mei Ou, Silvia Quadrelli, Georgios Kyriazis, Chang-Ho Kim, Daniel Staub, Jung-Woo Lee, Nisha Arenja, Prashant N. Chhajed, Konstantinos Kostikas, Michael Tamm, Jonathan Cohen, Pirkko Brander, Jing-Min Deng, Seung Ick Cha, A. Bodzenta-Lukaszyk, Yilmaz Palanci, Jing Bai, Venetia Tsara, Ali İhsan Carkanat, William MacNee, Andreas Bergmann, T.L. Verhage, Paolo Laperuta, Jongmin Lee, Paschalis Steiropoulos, Jae-Yong Park, Demosthenes Bouros, Andriana I. Papaioannou, Gokhan Kirbas, J.H. Vercoulen, Hadice Selimoglu Sen, J. Molema, Daiana Stolz, Antonio Rotondo, Julia Meissner, Nikolaos Papanas, Mehmet Kucukoner, Beat Mueller, Nils G. Morgenthaler, M. Szmitkowski, Mikael Gencay, and Martin Brutsche

Subjects
Pulmonary and Respiratory Medicine, Traditional medicine, business.industry, Medicine, business
Published
2010
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2. Mechanisms of Endothelin-1 Elevation in Chronic Obstructive Pulmonary Disease Patients with Nocturnal Oxyhemoglobin Desaturation

Author

Georgia Trakada, Kostas Spiropoulos, and Markos Marangos

Subjects
Pulmonary and Respiratory Medicine, Polysomnography, Hypoxemia, medicine, Humans, Lung Diseases, Obstructive, Hypoxia, Aged, COPD, Endothelin-1, medicine.diagnostic_test, business.industry, Respiratory disease, Middle Aged, Hypoxia (medical), medicine.disease, Endothelin 1, Pulmonary hypertension, respiratory tract diseases, Oxyhemoglobins, Anesthesia, Bronchoconstriction, medicine.symptom, Sleep, business
Abstract

Background: Nonapneic, oxyhemoglobin desaturation associated with sleep has been described in patients with chronic obstructive pulmonary disease (COPD). Hypoxemia stimulates endothelin-1 (ET-1) secretion. Once released, ET-1 can act locally to elicit sustained pulmonary artery vasoconstriction, bronchoconstriction and activation of alveolar macrophages. Objective: The aim of this study was to examine a possible correlation between ET-1 levels and nocturnal, nonapneic, oxyhemoglobin desaturation during sleep, in patients with COPD. Methods: We examined 48 COPD patients with formal polysomnography (EEG, ECG, airflow, respiratory muscle movement, oximeter) to detect the presence of nocturnal, nonapneic, oxyhemoglobin desaturation. Twelve of them were disqualified because of inadequate sleep or sleep apnea syndrome. Nineteen of them desaturated below a baseline sleep saturation of 90% for 5 min or more, reaching a nadir saturation of at least 85%. We collected arterial samples to measure ET-1 levels, after 5 min of the first period of desaturation, in each of the 19 patients. We also collected arterial samples in the morning, before the study, to measure baseline ET-1 levels in all patients. Results: Baseline arterial ET-1 levels during the day were very significantly higher in ‘desaturator’ COPD patients (2.058 ± 0.252 pg/ml) compared to ‘non-desaturator’ COPD patients (1.382 ± 0.159 pg/ml; p < 0.001). Also in ‘desaturator’ COPD patients ET-1, levels during the night were significantly higher (4.297 ± 1.107 pg/ml) compared to those during the day (p ≤ 0.001) and a significant negative correlation was observed between ET-1 levels and degree of desaturation (p < 0.0001, r = 0.9305). Conclusions: According to our study we can conclude that (1) ET-1 levels are significantly higher in ‘desaturator’ COPD patients both during the day and during the night, and (2) ET-1 levels correlate negatively significant with the degree of the oxyhemoglobin desaturation. These findings are consistent with the hypothesis that ET-1 plays a very important role in the pathophysiological manifestations of COPD patients.

Published
2001
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3. Subject Index Vol. 80, 2010

Author

Yilmaz Palanci, Cengizhan Sezgi, Stephanie P. Pezzo, Zhi-Yi He, Daniel Navajas, Anna Bodzenta-Lukaszyk, Christophe von Garnier, Irene Gerogianni, Cristina Embid, Konstantinos I. Gourgoulianis, Tae-Hoon Jung, Micha T. Maeder, Paschalina Tsopa, Jae-Yong Park, Abdurrahman Abakay, Roberto Duranti, Ramon Farré, Mirjam Christ-Crain, Osnat Moreh-Rahav, Daniel Staub, Christian Mueller, Pirkko Brander, Mark J. Rumbak, Joaquín Durán, Alfonso Fiorelli, Demosthenes Bouros, Jung-Woo Lee, Xiao-Ning Zhong, Evangelia Nena, Shaul Lev, Theodoros Kiropoulos, Pier Francesco Rambaldi, Kyung Min Shin, Silvia Quadrelli, Juan F. Masa, Guang-Nan Liu, B. Mroczko, Ilya Kagan, Ali İhsan Carkanat, Giovanni Vicidomini, Luigi Mansi, Roman Skiepko, Mohsen Davoudi, Richard G. Hegele, Prashant N. Chhajed, Konstantinos Kostikas, Georgia Trakada, T.L. Verhage, M.M. Tomasiak-Lozowska, Luigi Busiello, Pierre Singer, Olga Hatzizisi, Mei-Hua Li, Marios Froudarakis, Paschalis Steiropoulos, Ziemowit Zietkowski, Andriana I. Papaioannou, Nisha Arenja, Li-Mei Ou, Brice Taylor, Andrea Azzola, H.A.C. van Helvoort, Nazanin Zamanian Rohani, Michael Tamm, Jonathan Cohen, Z. Zietkowski, Milana Grinev, Jing-Min Deng, Abdullah Cetin Tanrikulu, Argyris Tzouvelekis, Mario Santini, Seung Ick Cha, J.B. Peters, Henri G. Colt, R. Skiepko, Y.F. Heijdra, Jian-Quan Zhang, J.M. Montserrat, Hadice Selimoglu Sen, Shin-Yup Lee, Daiana Stolz, Antonio Rotondo, Julia Meissner, J.H. Vercoulen, Georgios Kyriazis, David Dahan, Michael Roth, Paula Virkkula, M Shapiro, Udo Schirp, Osman Evliyaoglu, Mehmet Ali Kaplan, Smaragda Oikonomidi, Juho T. Lehto, Miriam Reiter, Nikolaos Papanas, Irene Tsilioni, Arnoldo Guerrero, P.N.R. Dekhuijzen, Venetia Tsara, Andreas Bergmann, Maria M. Tomasiak-Lozowska, Chang-Ho Kim, A. Bodzenta-Lukaszyk, Hanna-Riikka Kreivi, Gokhan Kirbas, M. Szmitkowski, Mikael Gencay, Martin Brutsche, Yael A. Glickman, Thenral Socrates, Jing Bai, William MacNee, Paolo Laperuta, Jongmin Lee, J. Molema, Mehmet Kucukoner, Beat Mueller, and Nils G. Morgenthaler

Subjects
Pulmonary and Respiratory Medicine, Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
2010
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