1. Early physical rehabilitation dosage in the IntensiveCare Unit predicts hospital outcomes after criticalCOVID-19.
- Author
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Mayer KP, Haezebrouck E, Ginoza LM, Martinez C, Jan M, Michener LA, Fresenko L, Montgomery-Yates AA, Kalema AG, Pastva AM, Biehl M, Mart MF, and Johnson JK
- Abstract
Objective: to examine the relationship between physical rehabilitation parameters including a novel approach to quantifying dosage with hospital outcomes for patients with critical COVID-19., Design: Retrospective practice analysis from March 5, 2020, to April 15, 2021., Setting: Intensive care units (ICU) at four medical institutions., Patients: n = 3,780 adults with ICU admission and diagnosis of COVID-19., Interventions: We measured the physical rehabilitation treatment delivered in ICU and patient outcomes: 1) mortality; 2) discharge disposition; and 3) physical function at hospital discharge measured by the Activity Measure-Post Acute Care (AM-PAC) "6-Clicks" (6-24, 24=greater functional independence). Physical rehabilitation dosage was defined as the average mobility level scores in the first three sessions (a surrogate measure of intensity) multiplied by the rehabilitation frequency (PT + OT frequency in hospital)., Measurements and Main Results: The cohort was a mean 64 ± 16 years old, 41% female, mean BMI of 32 ± 9 kg/m
2 and 46% (n=1739) required mechanical ventilation. For 2191 patients with complete data, rehabilitation dosage and AM-PAC at discharge were moderately, positively associated (Spearman's rho [r] = 0.484, p < 0.001). Multivariate linear regression (model adjusted R2 = 0.68, p <0.001) demonstrates mechanical ventilation (β = -0.86, p = 0.001), average mobility score in first three sessions (β = 2.6, p <0.001) and physical rehabilitation dosage (β = 0.22, p = 0.001) were predictive of AM-PAC scores at discharge when controlling for age, sex, BMI, and ICU LOS., Conclusions: Greater physical rehabilitation exposure early in the ICU is associated with physical function at hospital discharge., Competing Interests: Competing interests: None- Published
- 2024
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