1. Energy coupling in ABC exporters.
- Author
-
van Veen HW, Singh H, Agboh K, Fagg LA, Guo D, Swain B, de Kruijf RF, and Guffick C
- Subjects
- Adenosine Triphosphate metabolism, Anti-Bacterial Agents pharmacology, Biological Transport physiology, Protein Conformation, ATP-Binding Cassette Transporters metabolism, Anti-Bacterial Agents metabolism, Bacteria metabolism, Drug Resistance, Multiple, Bacterial physiology, Energy Metabolism physiology
- Abstract
Multidrug transporters are important and interesting molecular machines that extrude a wide variety of cytotoxic drugs from target cells. This review summarizes novel insights in the energetics and mechanisms of bacterial ATP-binding cassette multidrug transporters as well as recent advances connecting multidrug transport to ion and lipid translocation processes in other membrane proteins., (Copyright © 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF