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An exploration on course design model is proposed for new and interdisciplinary subjects such as human factors engineering, in order to cultivate students’ knowledge of “Knowing-Judgment-Improvement-Design”. The paper mainly focuses on the open design subject type, to bring forward the time of course design assignments, to pay attention to students ’ research habit forming of finding problem , to emphasis course design specification ’ s logic, diverse and visualization, and to attach much weight on value judgment of students’ spirit of exploration and research during course design period. The practice proved that the new course design model can significantly improve students’ interest, ability and consciousness on applying theoretical knowledge to solve practical problems. [ABSTRACT FROM AUTHOR]