1. Effect of dialysis on erythrocyte membrane of chronically hemodialyzed patients
- Author
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Fakhry F. Ibrahim, Fadel M. Ali, and Magdy M. Ghannam
- Subjects
Adult ,Male ,medicine.medical_specialty ,Membrane Fluidity ,medicine.medical_treatment ,Critical Care and Intensive Care Medicine ,Renal Dialysis ,Internal medicine ,Erythrocyte Deformability ,Membrane fluidity ,medicine ,Erythrocyte deformability ,Humans ,Uremia ,Osmotic concentration ,business.industry ,Erythrocyte Membrane ,Erythrocyte fragility ,General Medicine ,Middle Aged ,medicine.disease ,Hemodialysis Solutions ,Red blood cell ,Osmotic Fragility ,medicine.anatomical_structure ,Endocrinology ,Biochemistry ,Solubility ,Nephrology ,Kidney Failure, Chronic ,Female ,Hemodialysis ,business ,Dialysis (biochemistry) - Abstract
The present work examines the role of uremia and the effect of dialysis treatment on red blood cells (RBCs) membrane properties of hemodialysis patients. The results showed that, the uremic patients had a lower values of erythrocyte deformability than that of healthy control subject. The median osmotic fragility (MOF) showed a significant increase in hemodialyzed patients than that for control group. The osmotic resistance to hemolysis was improved after dialysis. The solubilization process of the RBCs membrane showed that the detergent concentration needed to solubilize the RBCs membrane for uremic patient was much higher than that for control group. The abnormalities of the present results for RBCs membrane properties are mostly related to membrane fluidity, which are slightly improved after dialysis. Biochemical analysis showed a decreasing trend in RBCs count, urea nitrogen, creatinine, potassium
- Published
- 2002