1. Age-related change in 7B2 (a novel pituitary polypeptide) concentrations in human cerebrospinal fluid
- Author
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Stephen R. Bloom, Haruo Iguchi, Shoichi Natori, Shin-nosuke Kurose, and Hajime Nawata
- Subjects
Male ,Aging ,medicine.medical_specialty ,Physiology ,Clinical Biochemistry ,Nerve Tissue Proteins ,Biochemistry ,Gel permeation chromatography ,Neuroendocrine Secretory Protein 7B2 ,Cellular and Molecular Neuroscience ,Endocrinology ,Cerebrospinal fluid ,Reference Values ,Age related ,Internal medicine ,Mole ,medicine ,Humans ,Chemistry ,Radioimmunoassay ,Pituitary Hormones ,Sephadex ,Reference values ,Female ,Quantitative analysis (chemistry) - Abstract
Concentrations of 7B2 (a novel pituitary polypeptide) immunoreactivity (7B2-IR) were measured using a specific 7B2 radioimmunoassay (RIA) in cerebrospinal fluids (CSFs) from 87 humans. The mean (+/- S.E.M.) concentration of 7B2-IR in CSF was 2022 +/- 68 pM and a statistically significant decrease with aging was observed in those concentrations (R = -0.28, t = 2.73, P less than 0.01), although it was not a strong relation based on the R-value. In the gel permeation chromatography of CSF on Sephadex G-100, a major peak with an apparent mol. wt. of 43 kDa (43K) and a minor peak with that of 11 kDa (11K) were observed.
- Published
- 1988