1. Lipid peroxidation and inflammatory molecules as markers of coronary artery disease
- Author
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Simona Gargiulo, Emiliano Aroasio, Barbara Sottero, Pietro Greco Lucchina, Giuseppe Poli, Roberto Pozzi, Fabio Ferrari, Gabriella Leonarduzzi, Paola Gamba, and Filippo Rabajoli
- Subjects
Male ,medicine.medical_specialty ,Physiology ,Clinical Biochemistry ,Coronary Disease ,Inflammation ,Disease ,medicine.disease_cause ,Biochemistry ,4-Hydroxynonenal ,Coronary artery disease ,Lipid peroxidation ,chemistry.chemical_compound ,Antigens, CD ,Reference Values ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Chemokine CCL2 ,Aged ,Aged, 80 and over ,Aldehydes ,Chemistry ,Cholesterol ,Monocyte ,Interleukin-8 ,Biochemistry (medical) ,Blood Proteins ,Cell Biology ,Middle Aged ,medicine.disease ,C-Reactive Protein ,Endocrinology ,medicine.anatomical_structure ,Female ,lipids (amino acids, peptides, and proteins) ,Lipid Peroxidation ,medicine.symptom ,Cell Adhesion Molecules ,Biomarkers ,Oxidative stress - Abstract
Oxidized low density lipoproteins (oxLDLs) may exert several pro-inflammatory effects that can contribute to the development of coronary artery disease (CAD). Evaluating a possible correlation between oxLDLs and clinical expression of CAD, we measured specific lipid peroxidation indices in healthy subjects and in patients at different clinical stages of CAD. We observed a slight, but not significant, increase in plasma content of cholesterol oxidation products, i.e. oxysterols, in all CAD patients, and a slight, but not significant, increase of 4-hydroxynonenal-protein adducts only in subjects with acute CAD. Moreover, CAD patients showed a plasma rise of specific inflammatory proteins, i.e. C-reactive protein, intercellular adhesion molecule-1, and interleukin-8, but not of monocyte chemotactic protein-1. These preliminary data, without excluding an involvement of oxidative stress and inflammation in CAD, do not show a strict correlation between relevant plasma markers, other than C-reactive protein, and acute phase of the disease.
- Published
- 2007