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1. Corrigendum to âEuropean contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)â [Redox Biol. 13 (2017) 94â162]

Author

J. Egea, I. Fabregat, Y.M. Frapart, P. Ghezzi, A. Görlach, T. Kietzmann, K. Kubaichuk, U.G. Knaus, M.G. Lopez, G. Olaso-Gonzalez, A. Petry, R. Schulz, J. Vina, P. Winyard, K. Abbas, O.S. Ademowo, C.B. Afonso, I. Andreadou, H. Antelmann, F. Antunes, M. Aslan, M.M. Bachschmid, R.M. Barbosa, V. Belousov, C. Berndt, D. Bernlohr, E. Bertrán, A. Bindoli, S.P. Bottari, P.M. Brito, G. Carrara, A.I. Casas, A. Chatzi, N. Chondrogianni, M. Conrad, M.S. Cooke, J.G. Costa, A. Cuadrado, P. My-Chan Dang, B. De Smet, B. Debelec-Butuner, I.H.K. Dias, J.D. Dunn, A.J. Edson, M. El Assar, J. El-Benna, P. Ferdinandy, A.S. Fernandes, K.E. Fladmark, U. Förstermann, R. Giniatullin, Z. Giricz, A. Görbe, H. Griffiths, V. Hampl, A. Hanf, J. Herget, P. Hernansanz-Agustín, M. Hillion, J. Huang, S. Ilikay, P. Jansen-Dürr, V. Jaquet, J.A. Joles, B. Kalyanaraman, D. Kaminskyy, M. Karbaschi, M. Kleanthous, L.O. Klotz, B. Korac, K.S. Korkmaz, R. Koziel, D. KraÄun, K.H. Krause, V. KÅen, T. Krieg, J. Laranjinha, A. Lazou, H. Li, A. Martínez-Ruiz, R. Matsui, G.J. McBean, S.P. Meredith, J. Messens, V. Miguel, Y. Mikhed, I. Milisav, L. MilkoviÄ, A. Miranda-Vizuete, M. MojoviÄ, M. Monsalve, P.A. Mouthuy, J. Mulvey, T. Münzel, V. Muzykantov, I.T.N. Nguyen, M. Oelze, N.G. Oliveira, C.M. Palmeira, N. Papaevgeniou, A. PaviÄeviÄ, B. Pedre, F. Peyrot, M. Phylactides, G.G. Pircalabioru, A.R. Pitt, H.E. Poulsen, I. Prieto, M.P. Rigobello, N. Robledinos-Antón, L. Rodríguez-Mañas, A.P. Rolo, F. Rousset, T. Ruskovska, N. Saraiva, S. Sasson, K. Schröder, K. Semen, T. Seredenina, A. Shakirzyanova, G.L. Smith, T. Soldati, B.C. Sousa, C.M. Spickett, A. Stancic, M.J. Stasia, H. Steinbrenner, V. StepaniÄ, S. Steven, K. Tokatlidis, E. Tuncay, B. Turan, F. Ursini, J. Vacek, O. Vajnerova, K. Valentová, F. Van Breusegem, L. Varisli, E.A. Veal, A.S. Yalçın, O. Yelisyeyeva, N. ŽarkoviÄ, M. Zatloukalová, J. Zielonka, R.M. Touyz, A. Papapetropoulos, T. Grune, S. Lamas, H.H.H.W. Schmidt, F. Di Lisa, and A. Daiber

Subjects
Medicine (General), R5-920, Biology (General), QH301-705.5
Published
2018
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2. Corrigendum to 'European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)' [Redox Biol. 13 (2017) 94–162]

Author

Alina Hanf, Alberto Bindoli, Miloš Mojović, David A. Bernlohr, Yuliya Mikhed, Paula M. Brito, Agnes Görlach, João G. Costa, Vladimír Křen, Rui M. Barbosa, Jose Viña, Khrystyna Semen, María Monsalve, Opeyemi S Ademowo, Andreas Petry, Jingjing Huang, Balaraman Kalyanaraman, Ioanna Andreadou, Javier Egea, Kateryna Kubaichuk, Antonio Martínez-Ruiz, Mutay Aslan, Helen R. Griffiths, Pietro Ghezzi, S. Ilikay, Rashid Giniatullin, Melanie Hillion, Shlomo Sasson, Verónica Miguel, John F. Mulvey, Huige Li, Nuno Saraiva, Kemal Sami Korkmaz, Brandán Pedre, Isabel T.N. Nguyen, Katrin Schröder, Maria Pia Rigobello, Holger Steinbrenner, João Laranjinha, Nikoletta Papaevgeniou, Péter Ferdinandy, Kateřina Valentová, Andrew R. Pitt, Nuno G. Oliveira, Amanda J. Edson, Gratiela Gradisteanu Pircalabioru, Paul G. Winyard, Matthias Oelze, Irundika H.K. Dias, Thomas Krieg, Joris Messens, Pidder Jansen-Dürr, Vaclav Hampl, Fernando Antunes, Yves Frapart, Thierry Soldati, Bilge Debelec-Butuner, Anabela P. Rolo, Tilman Grune, Jan Vacek, Thomas Münzel, Kahina Abbas, Marina Kleanthous, Anastasia Shakirzyanova, Neven Žarković, Belma Turan, Olga Vajnerova, F. Di Lisa, Irina Milisav, Thomas Kietzmann, Rhian M. Touyz, Lidija Milkovic, Antonio Cuadrado, Pierre-Alexis Mouthuy, Serge P. Bottari, Karl-Heinz Krause, Francis Rousset, Reiko Matsui, Catarina B. Afonso, Danylo Kaminskyy, Bebiana C. Sousa, F. Van Breusegem, Ana Sofia Fernandes, Antigone Lazou, Marcus Conrad, Isabel Fabregat, Bato Korac, Pablo Hernansanz-Agustín, Aleksandra Pavićević, Jaap A. Joles, Erkan Tuncay, Fabienne Peyrot, Anikó Görbe, Sebastian Steven, Harald H.H.W. Schmidt, Martina Zatloukalová, Jan Herget, Santiago Lamas, Kari E. Fladmark, Markus Bachschmid, Afroditi Chatzi, Geoffrey L. Smith, Fulvio Ursini, Joe Dan Dunn, Kostas Tokatlidis, Rafal Koziel, Andreas Papapetropoulos, Antonio Miranda-Vizuete, Jamel El-Benna, Vincent Jaquet, B. De Smet, Vladimir R. Muzykantov, Elizabeth A. Veal, Esther Bertran, Guia Carrara, Olha Yelisyeyeva, Haike Antelmann, Ana Stancic, A. S. Yalçin, M. El Assar, Ulla G. Knaus, Marcus S. Cooke, Vsevolod V. Belousov, Leocadio Rodríguez-Mañas, Lars-Oliver Klotz, Marios Phylactides, Manuela G. López, Marie José Stasia, Tatjana Ruskovska, Stuart P. Meredith, Lokman Varisli, Niki Chondrogianni, Mahsa Karbaschi, Rainer Schulz, Henrik E. Poulsen, Andreas Daiber, Natalia Robledinos-Antón, Corinne M. Spickett, Ulrich Förstermann, Višnja Stepanić, Tamara Seredenina, Carlos M. Palmeira, Gloria Olaso-Gonzalez, Ana I. Casas, Ignacio Prieto, Gethin J. McBean, Damir Kračun, P. My-Chan Dang, Jacek Zielonka, Zoltán Giricz, and Carsten Berndt

Subjects
0301 basic medicine, Societies, Scientific, Redox signaling, International Cooperation, Clinical Biochemistry, Nanotechnology, Review Article, Biology, Public administration, Biochemistry, Antioxidants, Article, 03 medical and health sciences, media_common.cataloged_instance, Animals, Humans, Cost action, European Union, European union, Molecular Biology, lcsh:QH301-705.5, media_common, Funding Agency, Redox therapeutics, lcsh:R5-920, Organic Chemistry, Reactive nitrogen species, 030104 developmental biology, Work (electrical), lcsh:Biology (General), Oxidative stress, Reactive Oxygen Species, lcsh:Medicine (General), Oxidation-Reduction, Signal Transduction
Abstract

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed., Graphical abstract fx1, Highlights • RONS are chemical mediators and a communication tool. • RONS and disturbed redox balance play a role in a broad range of diseases and aging. • Bacteria and toxins are important stimulators of cellular RONS formation. • Drugs should preserve beneficial redox signaling and inhibit detrimental RONS sources. • Redox drugs may target the origin, identity, location and time of RONS formation.

Published
2018
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3. Physical activity and exercise: Strategies to manage frailty.

Author

Angulo J, El Assar M, Álvarez-Bustos A, and Rodríguez-Mañas L

Subjects
Adaptation, Physiological, Aged, Exercise, Exercise Therapy, Frail Elderly, Humans, Frailty therapy, Sarcopenia prevention & control
Abstract

Frailty, a consequence of the interaction of the aging process and certain chronic diseases, compromises functional outcomes in the elderly and substantially increases their risk for developing disabilities and other adverse outcomes. Frailty follows from the combination of several impaired physiological mechanisms affecting multiple organs and systems. And, though frailty and sarcopenia are related, they are two different conditions. Thus, strategies to preserve or improve functional status should consider systemic function in addition to muscle conditioning. Physical activity/exercise is considered one of the main strategies to counteract frailty-related physical impairment in the elderly. Exercise reduces age-related oxidative damage and chronic inflammation, increases autophagy, and improves mitochondrial function, myokine profile, insulin-like growth factor-1 (IGF-1) signaling pathway, and insulin sensitivity. Exercise interventions target resistance (strength and power), aerobic, balance, and flexibility work. Each type improves different aspects of physical functioning, though they could be combined according to need and prescribed as a multicomponent intervention. Therefore, exercise intervention programs should be prescribed based on an individual's physical functioning and adapted to the ensuing response., Competing Interests: Declaration of competing interest No Conflicts Of Interest., (Copyright © 2020. Published by Elsevier B.V.)

Published
2020
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4. Short-term pharmacological activation of Nrf2 ameliorates vascular dysfunction in aged rats and in pathological human vasculature. A potential target for therapeutic intervention.

Author

Angulo J, El Assar M, Sevilleja-Ortiz A, Fernández A, Sánchez-Ferrer A, Romero-Otero J, Martínez-Salamanca JI, La Fuente JM, and Rodríguez-Mañas L

Subjects
Age Factors, Animals, Blood Circulation drug effects, Blood Vessels drug effects, Blood Vessels pathology, Disease Susceptibility, Endothelium metabolism, Female, Hemodynamics, Humans, Hydrogen Peroxide metabolism, Hydrogen Peroxide pharmacology, Male, Middle Aged, NF-E2-Related Factor 2 agonists, Nitric Oxide metabolism, Oxidative Stress, Rats, Vasodilation, Blood Vessels metabolism, Blood Vessels physiopathology, NF-E2-Related Factor 2 metabolism
Abstract

Oxidative stress contributes to endothelial dysfunction, a key step in cardiovascular disease development. Ageing-related vascular dysfunction involves defective antioxidant response. Nuclear factor erythroid 2-like-2 (Nrf2), orchestrates cellular response to oxidative stress. We evaluated the impact of Nrf2-activation on endothelium-dependent and H 2 O 2 -mediated vasodilations in: aorta (RA), mesenteric artery (RMA), coronary artery (RCA) and corpus cavernosum (RCC) from ageing rats and in human penile arteries (HPRA) and corpus cavernosum (HCC) from erectile dysfunction (ED) patients. Relaxant responses were evaluated in organ chambers and wire myographs. Nrf2 content and heme oxygenase-1 (HO-1) were determined by ELISA. Superoxide and Nrf2 were detected by immunofluorescence. Pharmacological activation of Nrf2 with sulforaphane (SFN) improved NO- and endothelium-derived hyperpolarizing factor-mediated endothelium-dependent vasodilation and H 2 O 2 -induced relaxation in vascular beds from aging rats. SFN-induced effects were associated with increased Nrf2 (RMA, RCA) and reduced superoxide detection in RCA. Improvement of vascular function was confirmed in HPRA and HCC from ED patients and mimicked by another Nrf2 activator, oltipraz. Nrf2 increase and superoxide reduction together with HO-1 increase by Nrf2 activation was evidenced in HCC from ED patients. PDE5 inhibitor-induced relaxations of HPRA and HCC from ED patients were enhanced by SFN. Nrf2 short-term pharmacological activation attenuates age-related impairment of endothelium-dependent and reactive oxygen species (ROS)-induced vasodilation in different rat and human vascular territories by upregulation of Nrf2-related signaling and decreased oxidative stress. In ED patients target tissues, Nrf2 potentiates the functional effect of ED conventional pharmacological therapy suggesting potential therapeutic implication., (Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2019
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5. Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

Author

Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, and Daiber A

Published
2018
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6. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Author

Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, and Daiber A

Subjects
Animals, European Union, Humans, Molecular Biology organization & administration, Molecular Biology trends, Oxidation-Reduction, Reactive Oxygen Species chemistry, Signal Transduction, Societies, Scientific, International Cooperation, Reactive Oxygen Species metabolism
Abstract

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed., (Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2017
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